Results 71 to 80 of about 2,746,777 (373)

Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases

open access: yesAntioxidants, 2017
Neurodegenerative diseases are incurable and devastating neurological disorders characterized by the progressive loss of the structure and function of neurons in the central nervous system or peripheral nervous system.
Ju Gao   +5 more
semanticscholar   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

DisAsymNet: Disentanglement of Asymmetrical Abnormality on Bilateral Mammograms using Self-adversarial Learning [PDF]

open access: yesarXiv, 2023
Asymmetry is a crucial characteristic of bilateral mammograms (Bi-MG) when abnormalities are developing. It is widely utilized by radiologists for diagnosis. The question of 'what the symmetrical Bi-MG would look like when the asymmetrical abnormalities have been removed ?' has not yet received strong attention in the development of algorithms on ...
arxiv  

Y-Chromosome Microdeletions: A Review of Prevalence, Screening, and Clinical Considerations

open access: yesThe Application of Clinical Genetics, 2021
Matthew J Rabinowitz, Phillip J Huffman, Nora M Haney, Taylor P Kohn The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence: Taylor P KohnJames Buchanan Brady Urological Institute ...
Rabinowitz MJ   +3 more
doaj  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle.

open access: yesNew England Journal of Medicine, 2004
BACKGROUND Patients with signs and symptoms of heart failure and a normal left ventricular ejection fraction are said to have diastolic heart failure. It has traditionally been thought that the pathophysiological cause of heart failure in these patients ...
M. Zile, C. Baicu, W. Gaasch
semanticscholar   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Abnormal Object Recognition: A Comprehensive Study [PDF]

open access: yesarXiv, 2014
When describing images, humans tend not to talk about the obvious, but rather mention what they find interesting. We argue that abnormalities and deviations from typicalities are among the most important components that form what is worth mentioning.
arxiv  

Computer Vision and Abnormal Patient Gait Assessment a Comparison of Machine Learning Models [PDF]

open access: yesarXiv, 2020
Abnormal gait, its associated falls and complications have high patient morbidity, mortality. Computer vision detects, predicts patient gait abnormalities, assesses fall risk and serves as clinical decision support tool for physicians. This paper performs a systematic review of how computer vision, machine learning models perform an abnormal patient's ...
arxiv  

An Abnormal Starfish [PDF]

open access: yesNature, 1886
A FEW weeks ago I dredged, off the north end of Arran, an interesting specimen of Porania pulvillus, Gray (= Goniaster templetoni, Forb.). It is rather more than 5 cm. in diameter, and one of the five short rays (that opposite to the madreporite), when viewed from the aboral surface, is seen to be distinctly bifurcated about 1 cm. from its termination.
openaire   +3 more sources

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