Results 111 to 120 of about 77,071 (250)
Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
Journal of Critical Public HealthIn the rapid rise of the “decolonizing Global Health” movement, a crucial predicament has emerged. Despite the field becoming increasingly understood as white supremacist at its core and built upon historic and contemporary colonial political ordering ...
Daniel Krugman
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Outlines of Abolition Democracy
OUTLINES OF ABOLITION DEMOCRACY Outlines of Abolition Democracy / Obst, Anthony James (Rights reserved) (-
Obst, Anthony James
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Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Golden Gulag in Italy? For the abolition of the Reception Industrial Complex
Borders must be abolished. Borders produce and are produced by carceral, racist, classist, sexist, and xenophobic regimes. Border Abolition Now demands transformative politics to dismantle these systems of oppression.
Francesco Marchi
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Climate Change and Lessons from the Abolition of Slavery [PDF]
A number of authors have made a comparison between the abolition of slavery and action to combat climate change. Most authors, however, make similar claims, suggesting that progress on climate change will require a transformation in moral perception ...
Lawlor, R. +3 more
core +1 more source
Advanced Science, EarlyView.Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong +20 more
wiley +1 more source