Results 101 to 110 of about 107,451 (261)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
The impact of welfare on the economic status of Aboriginal women [PDF]
, 1991 Despite the relatively low levels of employment among Aboriginal women, their average income, according to the 1986 Census, was not substantially lower than the average income of Australian women in general.
Daly, A. E.
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Social benefits of Aboriginal engagement in Natural Resource management [PDF]
, 2009 This paper examines the social benefits of Aboriginal engagement in natural resource management (NRM) in New South Wales (NSW). It first explores what may be meant by Aboriginal engagement in NRM and then outlines the NSW policy context in which that ...
Altman, Jon, May, Katherine, Hunt, Janet
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Negotiations between mining companies and Aboriginal communities: Process and structure [PDF]
, 1995 During recent years, Aboriginal communities in Australia have become increasingly involved in negotiating mineral development agreements with mining companies and relevant State agencies. Two factors influence the extent to which Indigenous interests can
O'Faircheallaigh, C.
core +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Estimating Northern Territory Government program expenditure for Aboriginal people: Problems and implications [PDF]
, 1992 There are currently no administrative mechanisms whereby data relating to State expenditure on programs for Aboriginal people are disaggregated. This paper attempts to assess the existing level of State Government expenditure on both mainstream and ...
Smith, Diane E
core