Results 41 to 50 of about 112,084 (259)

A Quality and Ergonomic Heart Monitoring Device with User-Friendly App for Telemedicine

Proceedings, 2019
During recent decades, the elderly population has grown rapidly, and the number of patients with chronic heart-related diseases has exploded. Many of them (e.g., congestive heart failure, some types of arrhythmia) require close medical supervision ...
Andres L. Bleda, Rafael Maestre, Javier Corral, Ricardo Ruiz   +3 more
doaj   +1 more source

Coordination of tissue homeostasis and growth by the Scribble-α-Catenin-Septate junction complex

iScience, 2023
Summary: Maintaining apicobasal polarity (ABP) is crucial for epithelial integrity and homeostasis during tissue development. Although intracellular mechanisms underlying ABP establishment have been well studied, it remains to be addressed how the ABP ...
Yunxian Huang, Jinghua Gui, Satu-Marja Myllymäki, Marja L. Mikkola, Osamu Shimmi   +4 more
doaj   +1 more source

De novo design of a homo-trimeric amantadine-binding protein. [PDF]

, 2019
The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved.
Adams, Afonine, Arzt, Bale, Boyken, Campbell, Davis, Delaglio, DeRose, Dou, Dou, Emsley, Fegan, Ghirlanda, Guerrero, Hsia, Jancarik, Lee, Mallet, McCoy, Meilleur, Mills, Miyamoto, Nyanguile, Ollikainen, Otwinowski, Perez-Lloret, Polizzi, Spencer, Stankunas, Thomaston, Tinberg, Tzeng, Wang, Waudby, Winn, Zhang   +36 more
core   +2 more sources

Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab

Pharmaceutical Research, 2019
The in vitro and in vivo pharmacologic assessment of ABP 980 similarity to its reference product is intended to compare the activity of ABP 980 and trastuzumab and support the overall conclusion of similarity based on a comprehensive analytical and ...
Shea Jassem, Wei Wang, H. Sweet, R. Manoukian, V. Chow, Palanisamy Kanakaraj, K. Hutterer, S. Kuhns, I. Foltz, Qing Chen, J. Ferbas, H. McBride   +11 more
semanticscholar   +1 more source

Eletroconvulsoterapia: eficácia, efeitos adversos, medidas de segurança, mecanismo de ação e complicações

Debates em Psiquiatria, 2012
O texto trata de aspectos da eletroconvulsoterapia, procedimento médico usado para tratamento de transtornos psiquiátricos graves. Dá continuidade ao artigo publicado em jan/fev/2011, desta mesma Revista, sobre o tema.
Mercêdes Jurema de Oliveira Alves, Paulo Silva Belmonte de Abreu   +1 more
doaj   +1 more source

ABP la evaluación del aprendizaje basado en problemas - ABP ABP-experimentación y validación.

Iatreia, 2004
Ofelia Villegas Muñoz
doaj   +1 more source

Totality of Scientific Evidence in the Development of ABP 980, a Biosimilar to Trastuzumab

Targeted oncology, 2019
ABP 980 was developed as a biosimilar to trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor 2 (HER2), that is indicated for the treatment of HER2-positive metastatic breast cancer, early breast cancer (EBC), and ...
H. Kolberg, M. Colleoni, P. Santi, G. Demetriou, M. Seguí-Palmer, Y. Fujiwara, S. Hurvitz, V. Hanes   +7 more
semanticscholar   +1 more source

A randomized, single-blind, single-dose study evaluating the pharmacokinetic equivalence of proposed biosimilar ABP 980 and trastuzumab in healthy male subjects

Cancer Chemotherapy and Pharmacology, 2017
PurposeThis study compared the pharmacokinetic (PK) profiles of the proposed biosimilar ABP 980 and trastuzumab in healthy males.MethodsIn this single-blind study, 157 healthy males were randomized 1:1:1 to a single 6 mg/kg intravenous infusion of ABP ...
V. Hanes, V. Chow, N. Zhang, R. Markus
semanticscholar   +1 more source

Environmental effectiveness of GAEC cross-compliance Standard 4.2 on biodiversity in set-aside management and economic evaluation of the competitiveness gap for farmers, part I

Italian Journal of Agronomy, 2016
In 2005, the CAP reform introduced the principle of conditionality that enables the access to single payments for farmers only ‘on condition’ that a series of commitments, such as the Statutory Management Requirements (SMR) and Good Agricultural and ...
Stefano Mocali, Silvia Landi, Arturo Fabiani, Raimondo Piccolo, Alessandro Agnelli, Giada d'Errico, Giuseppe Mazza, Marco Fedrizzi, Giulio Sperandio, Mirko Guerrieri, Mauro Pagano, Daniele Puri, Paolo Bazzoffi, Marta Biaggini, Pietro Lo Cascio, Claudia Corti   +15 more
doaj   +1 more source

Deletion of the TRPV1 channel attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure. [PDF]

J Physiol
Abstract figure legend Using wild‐type and Trpv1−/− rats, we assessed the contribution of TRPV1 channels to the activation of afferent renal nerve activity (ARNA) during renal artery occlusion, graded reductions in renal blood flow and elevated renal pelvic pressure.
Sullivan JB, DeLalio LJ, Stocker SD.
europepmc   +2 more sources