Results 51 to 60 of about 5,427 (131)

A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy

Drug Delivery, 2019
Proteins such as albumin, gelatin, casein, transferrin, and collagen are widely used as drug delivery systems. However, only albumin-based paclitaxel (PTX) formulation Abraxane® (PTX-albumin NPs prepared by nab-technology) has been successfully developed
Yongmei Zhao, Gang Chen, Zhengjie Meng, Guangming Gong, Wei Zhao, Kaikai Wang, Tianqing Liu   +6 more
doaj   +1 more source

Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics

Frontiers in Pharmacology, 2018
Over the past decade, more interests have been aroused in engineering protein-based nanoformulations for cancer treatment. This excitement originates from the success of FDA approved Abraxane (Albumin-based paclitaxel nanoparticles) in 2005.
Yi Gou, Dandan Miao, Min Zhou, Lijuan Wang, Hongyu Zhou, Gaoxing Su   +5 more
doaj   +1 more source

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 254-264, June 2026.
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chang Chen, Maosong Yang, Jiheng Wang, Ling Zhang, Shaobo Huang, Xiao Xu, Yang Liu   +6 more
wiley   +1 more source

A comparison between single and fractionated doses of albumin-bound paclitaxel in the treatment of advanced esophageal cancer: A multicenter case–control study

Science Progress
Purpose At present, albumin-bound paclitaxel combined with platinum is the standard first-line treatment option for advanced esophageal cancer (EC). However, following a hospitalization surge, clinicians may prefer to use albumin-bound paclitaxel as a ...
Jing Ren, Ke Wang, Jian Zhao, Chang Xu, Changqing Liu, Yusheng Wang, Guangyu Wang   +6 more
doaj   +1 more source

Nab-paclitaxel: A revolution in the nano-therapeutic approach to IDH-wildtype glioblastoma

Folia Neuropathologica
Paclitaxel (PTX) is a potent chemotherapy drug commonly used to treat various solid tumours, including breast and ovarian cancers. However, its effectiveness in treating IDH-wildtype glioblastoma has been limited due to challenges crossing the blood ...
Maria Fareed Siddiqui, Amber Hassan, Muzna Tahir, Fahad Okal, Saleh Baeesa, Alaa Alkhotani, Zayd Jasaniah, Ahmad Fallatah, Eyad Faizo, Dahlia Mirdad, Bashayer A. Althaqafi, Maher Kurdi   +11 more
doaj   +1 more source

Wolf in Sheep’s Clothing: Taming Cancer’s Resistance with Human Serum Albumin?

International Journal of Nanomedicine
Iga Stukan,1 Anna Żuk,2 Kamila Pukacka,3 Julia Mierzejewska,4 Jakub Pawłowski,4 Bogusław Kowalski,4 Maria Dąbkowska4 1Department of General Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland; 2Independent ...
Stukan I, Żuk A, Pukacka K, Mierzejewska J, Pawłowski J, Kowalski B, Dąbkowska M   +6 more
doaj  

Albumin-bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer

International Journal of Nanomedicine, 2009
Evelina Miele1, Gian Paolo Spinelli1, Ermanno Miele2, Federica Tomao1, Silverio Tomao11Department of Experimental Medicine, University of Rome “Sapienza”, Rome, Italy; 2Biomedical Engineering, University of Rome Tor Vergata, Rome ...
Evelina Miele, Gian Paolo Spinelli, Ermanno Miele, Federica Tomao, Silverio Tomao   +4 more
doaj  

Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges

International Journal of Pharmaceutics: X
The clinical advancement of protein-based nanomedicine has revolutionized medical professionals' perspectives on cancer therapy. Protein-based nanoparticles have been exploited as attractive vehicles for cancer nanomedicine due to their unique properties
Zhechen Fan, Haroon Iqbal, Jiang Ni, Naveed Ullah Khan, Shahla Irshad, Anam Razzaq, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Ali A. Shati, Jianping Zhou, Hao Cheng   +10 more
doaj   +1 more source

Sub-Tenon Injections of Triamcinolone Acetonide Had Limited Effect on Cystoid Macular Edema Secondary to Nanoparticle Albumin-Bound-Paclitaxel (Abraxane)

Case Reports in Ophthalmological Medicine, 2015
Purpose. To report the first case of cystoid macular edema (CME) induced by nanoparticle albumin-bound- (nab-) paclitaxel treated with sub-Tenon injections of triamcinolone acetonide (STTA) with detailed long-term follow-up. Case.
Naoki Matsuoka, Hiruma Hasebe, Tetsuji Mayama, Takeo Fukuchi   +3 more
doaj   +1 more source

Clinical efficacy of nab-paclitaxel in patients with metastatic pancreatic cancer

Drug Design, Development and Therapy, 2018
Rossella De Luca,1 Livio Blasi,2 Massimiliano Alù,2 Valerio Gristina,1 Giuseppe Cicero1 1Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy; 2Medical Oncology Unit, ARNAS ...
De Luca R, Blasi L, Alù M, Gristina V, Cicero G   +4 more
doaj