Results 181 to 190 of about 5,034 (216)
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Toxicon, 1971
Abstract Crystalline abrin contained 4·9 per cent of neutral sugar in addition to 9·3 residues of glucosamine per mole of abrin (molecular weight 65,000). The neutral sugars consist of mannose, xylose and fucose in ratios of 2·08:1·00:0·94. When abrin was treated with periodate, the residual toxicity was only a few per cent of that of native abrin ...
J Y, Lin, Y C, Cheng, K, Liu, T C, Tung
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Abstract Crystalline abrin contained 4·9 per cent of neutral sugar in addition to 9·3 residues of glucosamine per mole of abrin (molecular weight 65,000). The neutral sugars consist of mannose, xylose and fucose in ratios of 2·08:1·00:0·94. When abrin was treated with periodate, the residual toxicity was only a few per cent of that of native abrin ...
J Y, Lin, Y C, Cheng, K, Liu, T C, Tung
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Toxicological Reviews, 2003
Abrin is a toxic protein obtained from the seeds of Abrus precatorius (jequirity bean), which is similar in structure and properties to ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentional poisoning.
Kirsten J, Dickers +4 more
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Abrin is a toxic protein obtained from the seeds of Abrus precatorius (jequirity bean), which is similar in structure and properties to ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentional poisoning.
Kirsten J, Dickers +4 more
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Fatal abrin poisoning by injection
Clinical Toxicology, 2020Abrin is a toxin of public health concern due to its lethality, lack of antidote, and potential for use as a bioterrorism agent. Possible routes of exposure include ingestion, inhalation, and injection. Onset of symptoms is often delayed, even in severe cases. In fatal cases, death occurs from multi-organ failure.
Ginger R, Rinner +12 more
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Journal of the Forensic Science Society, 1971
A method is described for the detection of abrin, the toxic principle of Abrus precatorius , in biological material.
E G, Clarke, D J, Humphreys
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A method is described for the detection of abrin, the toxic principle of Abrus precatorius , in biological material.
E G, Clarke, D J, Humphreys
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ISOLATION OF ANTITUMOR PROTEINS ABRIN‐A AND ABRIN‐B FROM ABRUS PRECATORIUS*
International Journal of Peptide and Protein Research, 1978Two toxic proteins were purified from the seeds of Abrus precatorius by DEAE‐A 50 and Sepharose 4B chromatography. One of them does not bind on the Sepharose 4B column (Abrin‐b) and the other (Abrin‐a) is eluted with 0.2 M galactose. The amino acid compositions and tryptic maps of these two proteins were similar, but not identical.
J Y, Lin, T C, Lee, T C, Tung
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Journal of Crystallographic and Spectroscopic Research, 1993
The crystal structure of abrine (N-methyl L-tryptophan, (C12H14N2O2) was determined by X-ray diffraction. Space groupP212121,a=5.372(1),b=8.595(1) andc=24.082(2)A,Z=4,D m=1.30(4) gcm−3,D x=1.304 gcm−3,R=0.039 andwR=0.042. The conformational parameters for this structure following the IUPAC nomenclature areφ=67.7(5)°, ϰ1=−175(4)°, K21=105.2(7)° and χ22=−
J. Seetharaman +2 more
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The crystal structure of abrine (N-methyl L-tryptophan, (C12H14N2O2) was determined by X-ray diffraction. Space groupP212121,a=5.372(1),b=8.595(1) andc=24.082(2)A,Z=4,D m=1.30(4) gcm−3,D x=1.304 gcm−3,R=0.039 andwR=0.042. The conformational parameters for this structure following the IUPAC nomenclature areφ=67.7(5)°, ϰ1=−175(4)°, K21=105.2(7)° and χ22=−
J. Seetharaman +2 more
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Journal of Toxicology: Toxin Reviews, 1994
AbstractA family of toxic proteins, the isoabrins, which possess N-glycosylase activity toward eukaryotic 28S rRNA, may have potential use in cancer chemotherapy. By polymerase chain reaction techniques, cDNA clones of three isoabrins, carrying A and B-chain sequences, were isolated and their nucleotide sequences were determined.
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AbstractA family of toxic proteins, the isoabrins, which possess N-glycosylase activity toward eukaryotic 28S rRNA, may have potential use in cancer chemotherapy. By polymerase chain reaction techniques, cDNA clones of three isoabrins, carrying A and B-chain sequences, were isolated and their nucleotide sequences were determined.
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In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection
Biosensors and Bioelectronics, 2007Abrin toxin as the target protein, belongs to class II ribosome-inactivating proteins family, has high toxicity to eukaryotic cells. Here, we firstly report the DNA aptamers, isolated by in vitro selection, recognize abrin toxin with high affinity and specificity, and have the advantage of no cross-reaction with structure-similar protein ricin toxin ...
Tang, Jijun +5 more
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Medicine, 2007
Ricin is a type 2 ribosome-inactivating protein derived from the beans of the castor oil plant, Ricinus communis. It exerts toxicity by inhibiting protein synthesis. Many of the features seen in poisoning can be explained by ricin-induced endothelial cell damage, which leads to fluid and protein leakage and tissue oedema, causing so-called ‘vascular ...
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Ricin is a type 2 ribosome-inactivating protein derived from the beans of the castor oil plant, Ricinus communis. It exerts toxicity by inhibiting protein synthesis. Many of the features seen in poisoning can be explained by ricin-induced endothelial cell damage, which leads to fluid and protein leakage and tissue oedema, causing so-called ‘vascular ...
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Radioimmunoassays of abrin and ricin in blood
Journal of Toxicology and Environmental Health, 1981Radioimmunoassays for abrin and ricin are described. There is little cross-reactivity between the two toxins. The procedures described are capable of determining blood concentrations down to 50-100 pg/ml, permitting identification of abrin and ricin poisoning and monitoring of the blood concentrations in cancer patients treated with these agents.
A, Godal, S, Olsnes, A, Pihl
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