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Abrin and ricin — two toxic lectins
Trends in Biochemical Sciences, 1978Abrin and ricin are two peculiar proteins, each having two peptide chains with different functions. One chain, the ‘effectomer', is an enzyme capable of inactivating eucaryotic ribosomes. The other chain, the ‘huptomer', is a lectin which binds the toxin to cells and facilitates the entry of the effectomer into the cytoplasm.
Sjur Olsnes, Alexander Pihl
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Sensitivity of Preimplantation Mouse Embryos to Abrin
Acta Pharmacologica et Toxicologica, 1985Abstract: The effect of the plant toxin abrin on preimplantation mouse embryos in vitro was studied. Two–cell embryos from C57BL/6J or B6CBA/Fl/Bom ♀ × B6CBA/Fl/Bom ♂ mice were exposed to abrin for 72 hrs in vitro, in medium containing abrin in concentrations ranging from 0.1 to 10,000 pg/ml.
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Massive fatal overdose of abrin with progressive encephalopathy
Clinical Toxicology, 2019Introduction: The jequirity bean (Abrus precatorius) seed contains abrin, a toxalbumin, that irreversibly binds the 60-s ribosomal subunit inhibiting protein synthesis. Neurologic manifestations of ingestions are rare.Case details: We present a case of a 20-year-old man with 24 h of vomiting, diarrhea and 2 h of hematemesis and hematochezia.
B Zane, Horowitz +5 more
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Abrin, Ricin, and their Associated Agglutinins
1977It has been known since ancient times that the seeds of Abrus precatorius L. (Semen Jequiriti)* and Ricinus communis L.† (castor bean) are highly toxic, and the seeds have been used in folk medicine against a wide variety of diseases and also for various non-medical purposes.
S. Olsnes, A. Pihl
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Differentiation, Quantification and Identification of Abrin and Abrus precatorius Agglutinin
Toxins, 2021Daniel Stern +2 more
exaly