International Clinical Neuroscience Journal, 2018 Background: Epilepsy is a common neurological disorder with a prevalence of 1% of the world population. Absence epilepsy is a form of generalized seizures with Spike wave discharge in EEG.
Saleh Lashkari +4 more
doaj +1 more source
Perspective: Is Cortical Hyperexcitability the Only Path to Generalized Absence Epilepsy? [PDF]
, 2020 John R. Huguenard
openalex +1 more source
ARHGEF9 disease: Phenotype clarification and genotype-phenotype correlation. [PDF]
, 2017 ObjectiveWe aimed to generate a review and description of the phenotypic and genotypic spectra of ARHGEF9 mutations.MethodsPatients with mutations or chromosomal disruptions affecting ARHGEF9 were identified through our clinics and review of the ...
Alber, Michael +21 more
core
The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. [PDF]
, 2016 The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing
Calton, Michele A +4 more
core +2 more sources
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Lafora Disease Masquerading as Hepatic Dysfunction [PDF]
, 2018 Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence.
Abdullah, Hafez Mohammad A. +6 more
core +1 more source
Seizure clusters in drug-resistant focal epilepsy. [PDF]
, 2016 We investigated clinical factors associated with seizure clustering in patients with drug-resistant focal epilepsy and any association between seizure clustering and outcome after surgery.
Asadi-Pooya +12 more
core +2 more sources
Abnormal cortical thickness connectivity persists in childhood absence epilepsy
Annals of Clinical and Translational Neurology, 2015 Childhood absence epilepsy (CAE) is a childhood‐onset generalized epilepsy. Recent fMRI studies have suggested that frontal cortex activity occurs before thalamic involvement in epileptic discharges suggesting that frontal cortex may play an important ...
E. Curwood +5 more
semanticscholar +1 more source
Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling
Advanced Science, EarlyView.Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang +17 more
wiley +1 more source
Amygdala Kindling Resistance in Rats with Genetic Absence Epilepsy: Role of Sex Differences
Archives of EpilepsyObjective: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) exhibit notable resistance to amygdala kindling-induced seizures compared to Wistar rats. However, the influence of sex difference on kindling resistance in GAERS remains unexplored.
Özge Sarıyıldız +5 more
doaj +1 more source