Results 71 to 80 of about 947,716 (287)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Enhanced Data-Processing Algorithms for Dispersive Interferometry Using a Femtosecond Laser

Sensors
Dispersive interferometry based on a femtosecond laser is extensively utilized for achieving absolute distance measurements with high accuracy. However, this method cannot measure arbitrary distances without encountering a dead zone, and deviations in ...
Tao Liu, Hiraku Matsukuma, Amane Suzuki, Ryo Sato, Wei Gao   +4 more
doaj   +1 more source

Absolute and Precise Terahertz-Wave Radar Based on an Amplitude-Modulated Resonant-Tunneling-Diode Oscillator

Photonics, 2018
We present the principle of a terahertz-wave radar and its proof-of-concept experimental verification. The radar is based on a 522 GHz resonant-tunneling-diode oscillator, whose terahertz output power can be easily modulated by superimposing the ...
Adrian Dobroiu, Ryotaka Wakasugi, Yusuke Shirakawa, Safumi Suzuki, Masahiro Asada   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Optical Angle Sensor Technology Based on the Optical Frequency Comb Laser

Applied Sciences, 2020
A mode-locked femtosecond laser, which is often referred to as the optical frequency comb, has increasing applications in various industrial fields, including production engineering, in the last two decades.
Yuki Shimizu, Hiraku Matsukuma, Wei Gao
doaj   +1 more source

Meningovascular Inflammation in Cerebral Amyloid Angiopathy‐Related Cortical Superficial Siderosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis.
Philipp Arndt, Eya Khadhraoui, Sebastian J. Müller, Katja Neumann, Hendrik Mattern, Sven G. Meuth, Valentina Perosa, Andreas Charidimou, Stefanie Schreiber   +8 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Rapid directional change degrades GPS distance measurement validity during intermittent intensity running.

PLoS ONE, 2014
Use of the Global Positioning System (GPS) for quantifying athletic performance is common in many team sports. The effect of running velocity on measurement validity is well established, but the influence of rapid directional change is not well ...
Jonathan C Rawstorn, Ralph Maddison, Ajmol Ali, Andrew Foskett, Nicholas Gant   +4 more
doaj   +1 more source

Towards precision distances and 3D dust maps using broadband Period--Magnitude relations of RR Lyrae stars [PDF]

, 2014
We determine the period-magnitude relations of RR Lyrae stars in 13 photometric bandpasses from 0.4 to 12 {\mu}m using timeseries observations of 134 stars.
Bloom, Joshua S., Klein, Christopher R.
core  

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source