Results 91 to 100 of about 111,651 (291)

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について [PDF]

, 1993
The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1.
Kimura, Ikuro, Kitani, Hikaru, Mifune, Takashi, Mitsunobu, Fumihiro, Tanizaki, Yoshiro   +4 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial. [PDF]

, 2020
BACKGROUND:Zinc deficiency impairs immune function and is common among children in South-East Asia. OBJECTIVES:The effect of zinc supplementation on immune function in young Laotian children was investigated.
Andreini, Anzilotti, Barffour, Beck, Black, Boulay, Brown, Butt, Castillo-Duran, Charles B Stephensen, Chidchamai Kewcharoenwong, Gammoh, Ganjana Lertmemongkolchai, Gertrud U Schuster, Gibson, Guy-Marino Hinnouho, Haase, Hojyo, Honscheid, International Zinc Nutrition Consultative Group, International Zinc Nutrition Consultative Group, Inthira Tussakhon, Janet M Peerson, Jia, K Ryan Wessells, Kenneth H Brown, King, Lu, Maizels, Maxwell A Barffour, Mayo-Wilson, Maywald, Mehta, Prasad, Rajamanickam, Raqib, Ravin, Richter, Rosenkranz, Rosenkranz, Sandstead, Sazawal, Sengchanh Kounnavong, Sheikh, Shi, Sonja Y Hess, Tahan, Tepaamorndech, Walker, Wan, Waraporn Samer, Wessells, Wessells, WHO, Wu   +54 more
core   +2 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Prospective Analysis of Stress and Immunity in Advanced Cancer [PDF]

, 2011
Objectives:The aims of this study were to assess chronic stress in a sample of advanced cancer patients, test the association between stress and NK cell immune markers over time, and examine whether stress predicts immune markers over time.Methods:A ...
Ikpeama, Uzoh Erick
core   +1 more source

The Use of Aerosolized Ribavirin in Respiratory Syncytial Virus Lower Respiratory Tract Infections in Adult Immunocompromised Patients: A Systematic Review [PDF]

, 2019
Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug ...
Avery, Lisa M., Hoffmann, Charles, Whalen, Karen M.   +2 more
core   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts. [PDF]

, 2005
SETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV and patients with active and previous tuberculosis (TB). DESIGN: Cross-
Ascurra, O, Gomani, P, Harries, A D, Humblet, P, Kusamale, J, Manzi, M, Nunn, P, Pasulani, O, Salaniponi, F M L, Scano, F, Teck, R, Zachariah, R   +11 more
core   +1 more source