Results 21 to 30 of about 1,880,232 (279)

K dwarfs and the chemical evolution of the Solar cylinder [PDF]

, 2002
K-dwarfs have life-times older than the present age of the Galactic disc, and are thus ideal stars to investigate the disc's chemical evolution. We have developed several photometric metallicity indicators for K dwarfs, based an a sample of accurate ...
Chiappini, C., Flynn, C., Kotoneva, E., Matteucci, F.   +3 more
core   +2 more sources

Prediction of absolute bioavailability of medicines in children: based on predicted pediatric clearance from adults [PDF]

Exploration of Drug Science
Aim: The objective of this study was to evaluate the predictive performance of a proposed method to predict absolute bioavailability of medicines in children (infants to adolescents).
Iftekhar Mahmood
doaj   +1 more source

Interpreting the dependence of mutation rates on age and time [PDF]

, 2015
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing
Gao, Ziyue, Przeworski, Molly, Sella, Guy, Wyman, Minyoung J.   +3 more
core   +5 more sources

The Environment of M85 optical transient 2006-1: constraints on the progenitor age and mass [PDF]

, 2007
M85 optical transient 2006-1 (M85 OT 2006-1) is the most luminous member of the small family of V838 Mon-like objects, whose nature is still a mystery.
A. Jordan, A. Rau, Brown N. J., D. Magee, E. O. Ofek, E. W. Peng, J. P. Blakeslee, L. D. Bradley, L. Ferrarese, P. Cote, R. Bouwens, S. B. Cenko, S. Mei, S. R. Kulkarni, T. Puzia   +14 more
core   +3 more sources

Measures of Admission Immunocoagulopathy as an Indicator for In-Hospital Mortality in Patients with Necrotizing Fasciitis

JBJS Open Access, 2023
Background:. Necrotizing fasciitis is a rapidly progressive infection with a high mortality rate. Pathogens evade the host containment and bactericidal mechanisms by hijacking the coagulation and inflammation signaling pathways, leading to their rapid ...
Samuel R. Johnson, BS, Teresa Benvenuti, BA, Hui Nian, PhD, Isaac P. Thomson, MD, MSCI, Keith Baldwin, MD, MPH, MSPT, William T. Obremskey, MD, MPH, MMHC, Jonathan G. Schoenecker, MD, PhD, Stephanie N. Moore-Lotridge, PhD   +7 more
doaj   +1 more source

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants [PDF]

Drug Metabolism and Disposition, 2017
The age-dependent absolute protein abundance of carboxylesterase (CES) 1 and CES2 in human liver was investigated and applied to predict infant pharmacokinetics (PK) of oseltamivir. The CES absolute protein abundance was determined by liquid chromatography-tandem mass spectrometry proteomics in human liver microsomal and cytosolic fractions prepared ...
Mikael, Boberg, Marc, Vrana, Aanchal, Mehrotra, Robin E, Pearce, Andrea, Gaedigk, Deepak Kumar, Bhatt, J Steven, Leeder, Bhagwat, Prasad   +7 more
openaire   +2 more sources

Age estimation based on Willems method versus country specific model in Saudi Arabia children and adolescents

BMC Oral Health, 2021
Background The aims of this study were to create a method for estimation of dental age in Saudi children and adolescents based on the Willems model developed using the Belgian Caucasian (BC) reference data and to compare the ability of the two models to ...
Ali Alqerban, Muath Alrashed, Ziyad Alaskar, Khalid Alqahtani   +3 more
doaj   +1 more source

Empirical Isochrones for Low Mass Stars in Nearby Young Associations [PDF]

, 2015
Absolute ages of young stars are important for many issues in pre-main sequence stellar and circumstellar evolution but are long recognized as difficult to derive and calibrate.
Herczeg, Gregory J., Hillenbrand, Lynne A.   +1 more
core   +2 more sources

Deep learning-based age estimation from clinical Computed Tomography image data of the thorax and abdomen in the adult population.

PLoS ONE, 2023
Aging is an important risk factor for disease, leading to morphological change that can be assessed on Computed Tomography (CT) scans. We propose a deep learning model for automated age estimation based on CT- scans of the thorax and abdomen generated in
Bjarne Kerber, Tobias Hepp, Thomas Küstner, Sergios Gatidis   +3 more
doaj   +1 more source

Bayesian radiocarbon modeling and the absolute chronology of the Middle Bronze Age Thapsos facies in mainland Sicily: a view from St. Ippolito (Caltagirone)

, 2022
One of the most debated and explored period of the prehistory of Sicily is the Middle Bronze Age (15th-13th century BCE), which is considered as a crucial moment for the development of local prehistoric social, economic, and cross-cultural dynamics. The local Thapsos culture is what best represents this chronological period and is characterized at some
Tanasi, Davide, Alberti, Gianmarco, Caso, Giampiero, Tykot, Robert H., Trapani, Paolo, Amoroso, Domenico   +5 more
openaire   +2 more sources