Results 121 to 130 of about 1,274,743 (284)

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Human granulocyte colony-stimulating factor (rHuG-CSF) for treatment of neutropenia in Shwachman syndrome

Haematologica, 1995
We report a boy affected by Shwachman syndrome (SS) who presented severe neutropenia and frequent suppurative infections, which we treated successfully with granulocyte colony-stimulating factor (rHuG-CSF).
A Ventura, D Dragovich, P Luxardo, G Zanazzo   +3 more
doaj  

Assessment and predictive ability of the absolute neutrophil count in peripheral blood for in vivo CAR T cells expansion and CRS. [PDF]

J Immunother Cancer, 2023
Zhang M, Long X, Xiao Y, Jin J, Chen C, Meng J, Liu W, Liu A, Chen L.   +8 more
europepmc   +1 more source

Absolute Neutrophil Counts: Man Vs. Machine [PDF]

Biology of Blood and Marrow Transplantation, 2014
Odem, Penny, Mann, James
openaire   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

A high absolute lymphocyte count predicts a poor prognosis in HER-2- positive breast cancer patients treated with trastuzumab

, 2019
Jin Hong,1 Xiaosong Chen,1 Weiqi Gao,1 Siji Zhu,1 Jiayi Wu,1 Ou Huang,1 Jianrong He,1 Li Zhu,1 Weiguo Chen,1 Yafen Li,1 Xiaochun Fei,2 Lin Lin,3 Kunwei Shen11Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of ...
Wu J, Shen K, He J, Hong J, Fei X, Huang O, Li Y, Zhu L, Chen W, Gao W, Chen X, Lin L, Zhu S   +12 more
core  

Neutrophil extracellular traps in inflammatory disorders [PDF]

, 2014
A novel feature of polymorphonuclear granulocyte (PMN) biology is their ability to generate neutrophil extracellular traps (NETs) via a distinct process of cell death termed NETosis.
Sur Chowdhury, Chanchal
core   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Causal links and immune mediators between blood cells and breast cancer risk: a mendelian randomization study

Discover Oncology
Background Previous studies have indicated a potential association between blood cells and breast cancer risk, but the causal relationships involving specific blood cell metrics and the role of immune cell mediators remain unclear.
Meizi Song, Yu Liu, Jiaxu Dong, Jiafang Xu, Minghao Yang, Qingjie Hu, Siqi Yin, Xun Bi   +7 more
doaj   +1 more source

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality.

PLoS ONE, 2018
BackgroundThe mortality from cryptococcal meningitis remains high, despite the availability of antiretroviral therapy (ART) and amphotericin-based fungal regimens. The role of neutrophils in cryptococcosis is controversial.
Abdu Kisekka Musubire, David B Meya, Joshua Rhein, Graeme Meintjes, Paul R Bohjanen, Edwin Nuwagira, Conrad Muzoora, David R Boulware, Kathy Huppler Hullsiek, COAT and ASTRO trial teams   +9 more
doaj   +1 more source