Results 271 to 280 of about 175,779 (327)

Clinical management of CMML—State of the art

open access: yesBritish Journal of Haematology, EarlyView.
Patients with chronic myelomonocytic leukaemia (CMML) typically present with clinical feature including splenomegaly, constitutional symptoms and autoimmune phenomena, as well as with pathological blood counts and biological features in the marrow. These characteristics may influence the assignment to prognostic categories such as the CPSSmol and also ...
K. Nachtkamp   +3 more
wiley   +1 more source

Prevalence of myeloid gene alterations in paediatric cutaneous and systemic mastocytosis

open access: yesBritish Journal of Haematology, EarlyView.
A total of 69 children with paediatric mastocytosis, including cutaneous and systemic subtypes, were enrolled in a prospective natural history study (NCT00044122). They underwent next‐generation sequencing of peripheral blood to assess myeloid gene alterations.
Xiaoping Sun   +4 more
wiley   +1 more source

Efficacy and safety of HRS‐5965 monotherapy in complement inhibitor–naïve patients with paroxysmal nocturnal haemoglobinuria

open access: yesBritish Journal of Haematology, EarlyView.
Summary Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, life‐threatening disorder characterized by complement‐mediated haemolysis, leading to anaemia and thrombosis. HRS‐5965 is a novel, oral, selective complement factor B inhibitor targeting the alternative pathway, potentially reducing both intra‐ and extravascular haemolysis.
Li Zhang   +7 more
wiley   +1 more source

Management of Graves Disease With Co-Existing Duffy-Null Phenotype. [PDF]

open access: yesJCEM Case Rep
Ferri GM   +5 more
europepmc   +1 more source

Allogeneic transplantation after failure of chimeric antigen receptor‐T cells and exposure to bispecific antibodies: Feasibility, safety and survival outcomes

open access: yesBritish Journal of Haematology, EarlyView.
Summary Clinical outcome after chimeric antigen receptor (CAR)‐T‐cell failure in large B‐cell lymphoma (LBCL) is dismal. Allogeneic stem cell transplantation (alloSCT) represents a potentially curative salvage for relapsed/refractory LBCL, although concerns remain regarding its feasibility and safety in patients exposed to CAR‐T and bispecific ...
Angelica Barone   +10 more
wiley   +1 more source

Comorbidity patterns and immune-metabolic differences in patients with acute-episode of schizophrenia spectrum disorders. [PDF]

open access: yesSchizophrenia (Heidelb)
Wu G   +14 more
europepmc   +1 more source

Multi‐pronged analysis of pediatric low‐grade glioma and ganglioglioma reveals a unique tumor microenvironment associated with BRAF alterations

open access: yesBrain Pathology, EarlyView.
A multi pronged analysis approach revealed distinct neoplastic populations in PA and GG. Non‐neoplastic populations in PA showed higher levels of immune mobilizing chemokines in PA compared to GG. Abstract Pediatric low‐grade gliomas (pLGG) comprise 35% of all brain tumors.
Shadi Zahedi   +19 more
wiley   +1 more source

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