Results 91 to 100 of about 1,495,761 (300)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Absorbed dose rate in air in the Tokatsu area of Chiba Prefecture measured in 2015.

, 2017
Absorbed dose rate in air in the Tokatsu area of Chiba Prefecture measured in 2015.
Kyouko Saito (3701086), Kazumasa Inoue (3701080), Makoto Fujisawa (539932), Masahiro Fukushi (3202707), Moeko Arai (3701083)   +4 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Australian Commonwealth standard of measurement for absorbed radiation dose, Part 2 - absorbed dose standard for graphite irradiated by a cobalt-60 teletherapy unit.

, 1990
This report documents the absorbed dose standard for photon beams in the range from 1 to 25 MeV. Measurements of absorbed dose in graphite irradiated by a beam of cobalt-60 gamma rays from an Atomic Energy of Canada Limited (AECL) E1 Dorado 6 ...
Sherlock, SL
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Preliminary Study on the Quantitative Value Transfer Method of Absorbed Dose to Water in 60Co γ Radiation

Journal of Isotopes, 2015
Absorbed dose to water in 60Co γ radiation is the basic physics quantity in the quantitative value system of radiation therapy, it is very necessary for radiation therapy.
SONG Ming-zhe, YE Hong-sheng, GAO Fei
doaj  

Absorbed dose enhancement caused by gold particles in polymer gels.

, 2009
Previos studies showed that the presence of high-Z materials adjacent to soft tissues, when submitted to irradiation, enhances the absorbed dose in these tissues. This effect is due to the outscattering of photoelectrons from the high-Z materials.
Afonso, L.C., Hoeschen, C., Schöfer, F.H., Widmark, Anders,, Franzen, Lars,, Dasu, Alexandru,, Toma-Dasu, Iuliana, Nilsson, Per,   +7 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration.

, 2015
Background211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy.
Britta Langen, Helou, Khalil,, Forssell-Aronsson, Eva,, Khalil Helou, Rudqvist, Nils,, Emil Schüler, Toshima Z Parris, Eva Forssell-Aronsson, Eva Forssell-Aronsson (658141), Parris, Toshima Z,, Britta Langen (770438), Emil Schüler (658139), Schüler, Emil,, Johan Spetz (770437), Toshima Z. Parris (658140), Spetz, Johan,, Nils Rudqvist, Johan Spetz, Nils Rudqvist (770436), Khalil Helou (561963), Langen, Britta,, Forssell-Aronsson Eva, Parris Toshima Z., Spetz Johan, Helou Khalil, Rudqvist Nils, Schüler Emil, Langen Britta   +27 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source