Results 61 to 70 of about 1,495,761 (300)

OEDIPE, a software for personalized Monte Carlo dosimetry and treatment planning optimization in nuclear medicine: absorbed dose and biologically effective dose considerations

, 2014
For targeted radionuclide therapies, treatment planning usually consists of the administration of standard activities without accounting for the patient-specific activity distribution, pharmacokinetics and dosimetry to organs at risk.
A. Desbrée, C. de Labriolle Vaylet, A. Petitguillaume, D. Franck, M. Bernardini, Desbreé, A., Bernardini, M., Franck, D., D. Broggio, Broggio, D., Petitguillaume, A., de Labriolle Vaylet, C.   +11 more
core   +1 more source

Dependence of micronuclei assay on the depth of absorbed dose [PDF]

, 2017
AimThe purpose of the present study is to investigate the dependence of micronuclei response on the depth of absorbed dose.BackgroundOne of the most common cytogenetic methods used for radiation dosimetry is micronuclei (MN).
Yadolahi, Masoumeh; Nursing Care Research Center, Semnan University of Medical Sciences, Semnan, Iran, Aghamiri, Seyed Mahmoud; Radiation Medicine Department, University of Shahid Beheshti, Tehran, Iran, Mahmoudzadeh, Aziz; Department of Bioscience and Biotechnology, Malek-Ashtar University of Technology, Tehran, Iran, Abtahi, Seyed Mohammad; Physics Department, Imam Khomeini International University, Norouzian, P.O. Box 34148-96818, Qazvin, Iran   +3 more
core   +1 more source

A comparison of feeding activity (total bites) and estimated absorbed dose rate for annelid.

, 2022
A comparison of feeding activity (total bites) and estimated absorbed dose rate for annelid.
Sergey Gashchak (7909952), Michael D. Wood (10277834), Nicholas A. Beresford (3990632), Catherine L. Barnett (12126881)   +3 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Optimization of Parameters in 16-slice CT-‌‌scan Protocols for Reduction of the Absorbed Dose [PDF]

Iranian Journal of Medical Physics, 2014
Introduction In computed tomography (CT) technology, an optimal radiation dose can be achieved via changing radiation parameters such as mA, pitch factor, rotation time and tube voltage (kVp) for diagnostic images.
Shahrokh Naseri, Mahdi Momen Nezhad, Zahra Hozhabri, Abbas Haghparast, Golestan Karami, Peyman Hejazi   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simplified method for creating a density-absorbed dose calibration curve for the low dose range from Gafchromic EBT3 film

Journal of Medical Physics, 2016
Radiochromic film dosimeters have a disadvantage in comparison with an ionization chamber in that the dosimetry process is time-consuming for creating a density-absorbed dose calibration curve.
Tatsuhiro Gotanda, Toshizo Katsuda, Rumi Gotanda, Tadao Kuwano, Takuya Akagawa, Nobuyoshi Tanki, Akihiko Tabuchi, Tetsunori Shimono, Yasuyuki Kawaji   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source