Results 91 to 100 of about 3,830,075 (379)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little

International Journal of Pharmaceutics: X
Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska, Mathilde Leyh, Constantin Foja, Theodora Tzakri, Philipp Schick, Felix Morof, Julius Krause, James Mann, Richard Barker, Mladen Vassilev Tzvetkov, Werner Weitschies, Michael Grimm   +11 more
doaj   +1 more source

Electromagnetically Induced Transparency and Absorption in Metamaterials: The Radiating Two-Oscillator Model and Its Experimental Confirmation

, 2012
Several classical analogues of electromagnetically induced transparency in metamaterials have been demonstrated. A simple two-resonator model can describe their absorption spectrum qualitatively, but fails to provide information about the scattering ...
Jain, Aditya, Koschny, Thomas, Soukoulis, Costas M., Tassin, Philippe, Zhang, Lei, Zhao, Rongkuo   +5 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Phonon-assisted optical absorption in BaSnO$_3$ from first principles

, 2017
The perovskite BaSnO$_3$ provides a promising platform for the realization of an earth abundant $n$-type transparent conductor. Its optical properties are dominated by a dispersive conduction band of Sn $5s$ states, and by a flatter valence band of O $2p$
Dreyer, Cyrus E., Monserrat, Bartomeu, Rabe, Karin M.   +2 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The kinetic temperature in a damped Lyman-alpha absorption system in Q2206-199 - an example of the warm neutral medium

, 2012
By comparing the widths of absorption lines from OI, SiII and FeII in the redshift z=2.076 single-component damped Lyman alpha absorption system in the spectrum of Q2206-199 we establish that these absorption lines arise in Warm Neutral Medium gas at ...
A. M. Wolfe, Asplund, Becker, Begum, Carswell, Cooke, Cooke, Dessauges-Zavadsky, Diego, G. D. Becker, Hanuschik, Howk, Jones, Jorgenson, Kanekar, King, Lampton, Lehner, M. T. Murphy, McKee, Morton, Morton, Nehmé, O’Meara, Penprase, Petitjean, Pettini, Pettini, Pettini, Pettini, Prochaska, Prochaska, Prochaska, R. A. Jorgenson, R. F. Carswell, Rauch, Rauch, Redfield, Savage, Sembach, Tumlinson, Wolfe, Wolfe, Wolfe, Wolfire   +44 more
core   +1 more source

Accurate Computation of the Absorption Spectrum of Chlorophyll a with Pair Natural Orbital Coupled Cluster Methods [PDF]

, 2020
Abhishek Sirohiwal, Romain Berraud‐Pache, Frank Neese, Róbert Izsák, Dimitrios A. Pantazis   +4 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Large-scale structure in the Lyman-alpha forest II: analysis of a group of ten QSOs

, 1999
The spatial distribution of Ly-alpha forest absorption systems towards ten QSOs has been analysed to search for large-scale structure over the redshift range 2.2 < z < 3.4.
A. Fernandez-Soto, Bi H., Bowen D. V., Carswell R. F., Chernomordik V. V., Cowie L. L., Cristiani S., Cristiani S., Croft R. A. C., Crotts A. P. S., D'Odorico V., Dave R., Dave R., Dinshaw N., Elowitz R. M., G. M. Williger, Gnedin N. Y., Gnedin N. Y., Hu E. M., Hui L., Ikeuchi S., Ikeuchi S., J. K. Webb, J. Liske, Khare P., Kim T.-S., Kirkman D., Kulkarni V. P., Lanzetta K. M., Le Brun V., Le Brun V., Liske J., Lu L., Lu L., Meiksin A., Miralda-Escude J., Mo H. J., Morris S. L., Mucket J. P., Nusser A., Ostriker J. P., Pando J., Petitjean P., Petitjean P., R. F. Carswell, Rauch M., Rees M. J., Riediger R., Sargent W. L. W., Smette A., Songaila A., Theuns T., Theuns T., Tripp T. M., Ulmer A., Wadsley J. W., Webb J. K., Webb J. K., Williger G. M., Williger G. M., Williger G. M., York D. G., Zhang Y.   +62 more
core   +1 more source