Results 111 to 120 of about 1,836,494 (319)
Clinical and Translational ScienceCoproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may ...
Leila Potzel +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Development of a laser for differential absorption lidar measurement of atmospheric carbon dioxide [PDF]
, 2014 In the quest for a better understanding of climate change, greater importance is attached to monitoring the levels of atmospheric carbon dioxide to gain an improved knowledge of sources and sinks.
Cameron F. Rae +10 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Study on a Novel Absorption Referigeration System at Low Cooling Temperatures
, 2012 A novel absorption refrigeration system is proposed in this context using R134a+R23 mixed refrigerants and DMF solvent. The new system uses two-staged absorber in series to reduce the evaporation pressure and can obtain a lower refrigeration temperature ...
Chen, Guangming +3 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Intestinal barrier function and absorption in pigs after waeaning: a review
, 2011 Under commercial conditions, weaning of piglets is associated with social, environmental and dietary stress. Consequently, small-intestinal barrier and absorptive functions deteriorate within a short time after weaning.
Wijtten, P.J.A. +2 more
core +1 more source
The Influence of Multiscale Fillers Rein forcement into Impact Resistance and Energy Absorption Properties of Polyamide 6 and Polypropylene Nanocomposite Structures [PDF]
, 2013 Three-phase composites (thermoplastic polymer, glass-fibres and nano-particles) were investigated as an alternative to two-phase (polymer and glass-fibres) composites.
Sachse, Sophia +5 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Data mining methods for the prediction of intestinal absorption using QSAR [PDF]
, 2014 Oral administration is the most common route for administration of drugs. With the growing cost of drug discovery, the development of Quantitative Structure-Activity Relationships (QSAR) as computational methods to predict oral absorption is highly ...
Newby, Danielle Anne
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