Results 91 to 100 of about 1,016,885 (202)

Pharmacogenetic analyses in people with dementia in Northeast Germany

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Pharmacogenetics‐guided prescribing may reduce adverse drug reactions by 30%. European and American expert groups (Dutch Pharmacogenetics Working Group and Clinical Implementation Consortium) issue genotype‐based dosage recommendations, but ...
Marleen Julia Meyer‐Tönnies, Leefke Schwarz, Diana Wucherer, Wolfgang Hoffmann, Jochen René Thyrian, Mladen Vassilev Tzvetkov   +5 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Iron deficiency up-regulates iron absorption from ferrous sulphate but not ferric pyrophosphate and consequently food fortification with ferrous sulphate has relatively greater efficacy in iron-deficient individuals [PDF]

, 2010
Fe absorption from water-soluble forms of Fe is inversely proportional to Fe status in humans. Whether this is true for poorly soluble Fe compounds is uncertain.
Egli, I., Zimmermann, Michael B., Hurrell, R.F., Zeder, C., Michael B. Zimmermann, Ralf Biebinger, Richard F. Hurrell, Biebinger, Ralf, Zeder, Christophe, Ines Egli, Christophe Zeder, Egli, Ines, Hurrell, Richard F., Zimmermann, M.B., Biebinger, R.   +14 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

All-optical sampling utilising two-photon absorption in semiconductor microcavity [PDF]

, 2005
A highly-efficient optical sampling system based on Two-Photon Absorption in a semiconductor micro-cavity is presented.
Krug, T., Maguire, Paul, J., Donegan, John Francis, Folliot, Hervé, Donegan, J.F., Barry, Liam,, Bradley, A.L., Folliot, H., Lynch, M., Barry, Liam P., Lynch, Michael, Bradley, Ann Louise, Maguire, Paul,, Maguire, Paul J., Barry, Liam, P.   +14 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]

, 2015
The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
core   +1 more source

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study

Clinical and Translational Science
Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may ...
Leila Potzel, Jonny Kinzi, Isabell Seibert, Markus Grube, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Absorption of the structural funds in Romania [PDF]

The European structural policy was directed towards consolidating the specific objectives of narrowing the regional disparities, an ample process of negotiation for the allocation of the structural funds to the new member states, Romania included.
Nicolaescu, Victor, Cace, Corina, Cace, Sorin   +2 more
core