Results 101 to 110 of about 5,052,521 (413)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
IEEE Access, 2020 High field enhancement and near-perfect absorption in nanoantennas were realized by using in-plane (between nanoantenna arms), out-of-plane (between nanoantenna and reflector), and array coupling (between nanoantennas in an array); however, it was ...
Mohamad Khoirul Anam, Sangjo Choi
doaj +1 more source
Collisionless energy absorption in nanoplasma layer in regular and stochastic regimes [PDF]
arXiv, 2006 Collisionless energy absorption in 1D nanoplasma layer is considered. Straightforward classical calculation of the absorption rate in action-angle variables is presented. In regular regime the result obtained is the same as in [Zaretsky et.al., 2004], but deeper insight is possible now due to the technique used.
arxiv
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
A Detailed Thermal and Effective Induced Residual Spin Rate Analysis for LEO Small Satellites
IEEE Access, 2020 In space thermal environment, satellites are exposed to multiple heat sources which can deteriorate structural and equipment integrity over long periods of time.
Anwar Ali +4 more
doaj +1 more source
Galaxy Morphology - Halo Gas Connections
, 2005 We studied a sample of 38 intermediate redshift MgII absorption-selected galaxies using (1) Keck/HIRES and VLT/UVES quasar spectra to measure the halo gas kinematics from MgII absorption profiles and (2) HST/WFPC-2 images to study the absorbing galaxy ...
B. Ménard +5 more
core +2 more sources
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Light Trapping in Thin Film Disordered Nanohole Patterns: Effects of Oblique Incidence and Intrinsic Absorption [PDF]
arXiv, 2013 Finite-difference time-domain method is employed to investigate the optical properties of semiconductor thin films patterned with circular holes. The presence of holes enhances the coupling of the incident plane wave with the thin film and greatly enhances the absorption performance.
arxiv
FEBS Open Bio, EarlyView.ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu +6 more
wiley +1 more source
Clinical and Translational ScienceEzetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was shown to interact with the clinically relevant hepatic transporter organic anion transporting ...
Jonny Kinzi +4 more
doaj +1 more source