Results 81 to 90 of about 5,169,045 (382)

The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little

open access: yesInternational Journal of Pharmaceutics: X
Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water when taking their medications. Capsules (mainly gelatine- and HPMC-based) are widely used solid oral dosage forms.
Dorota Sarwinska   +11 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

A Model for Quantum Stochastic Absorption in Absorbing Disordered Media

open access: yes, 2004
Wave propagation in coherently absorbing disordered media is generally modeled by adding a complex part to the real part of the potential. In such a case, it is already understood that the complex potential plays a duel role; it acts as an absorber as ...
Prabhakar Pradhan   +2 more
core   +1 more source

Incidence of HI 21-cm absorption in strong FeII systems at $0.5 [PDF]

open access: yes, 2016
We present the results from our search for HI 21-cm absorption in a sample of 16 strong FeII systems ($W_{\rm r}$(MgII $\lambda2796$) $\ge1.0$ \AA\ and $W_{\rm r}$(FeII $\lambda2600$) or $W_{\rm FeII}$ $\ge1$ \AA) at $0 ...
Dutta, R.   +7 more
core   +1 more source

Analysis of dispersion and absorption characteristics of shear waves in sinusoidally corrugated elastic medium with void pores [PDF]

open access: yesRoyal Society Open Science, 2017
This theoretical work reports the dispersion and absorption characteristics of horizontally polarized shear wave (SH-wave) in a corrugated medium with void pores sandwiched between two dissimilar half-spaces.
Deepak Kr. Pandit   +2 more
doaj   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Discovery of Newly Formed Broad Absorption Lines in a Radio-Loud Quasar [PDF]

open access: yes, 2002
We report a serendipitous discovery of broad absorption lines that were newly formed in the spectrum of the high-redshift, luminous radio-loud quasar TEX 1726 + 344, in a time interval of only 12 years.
F. Ma, Ma
core   +3 more sources

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