Results 111 to 120 of about 271,263 (249)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Groundwater resources: Challenges & solutions
Cambridge Prisms: WaterThrough the provision of drinking and agricultural irrigation water, groundwater resources fundamentally underpin the existence of modern human society across large regions of the world.
Richard J. Cooper, Kevin M. Hiscock
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
IS PHYSICS FUNDAMENTAL? ROBERT RUSSELL ON DIVINE ACTION
Zygon, 2010 Robert Russell's theological work has been a helpful stimulus to the task of understanding the meaning of divine action and providence in the age of science.
doaj +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Reasoning by Analogy via Abstraction
, 1995 ion has been used in theorem proving as an heuristic to reduce the search space and as a tool for explanation. We use abstraction to model certain forms of reasoning by analogy.
Villafiorita Monteleone, Adolfo
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Building Thinking about Graphical Antiderivatives: The Role of Interval Perspectives
Annales de Didactique et de Sciences CognitivesThe concept of function traverses the mathematics studied at school and university and is an important transitional link between the two. We examine how an interval perspective on function may help with constructing graphical antiderivative functions. In
Mike Thomas +2 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Abstraction and non-sequitur [Elektronisk resurs]
, 2019 The paper looks at abstract meaning or references in comics to understand better the limitations for comics’ storytelling that might result from using higher forms of abstraction.
Dittmar, Jakob,
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