Results 111 to 120 of about 213,552 (301)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Shape predicates allow unbounded verification of linearizability using canonical abstraction
, 2014 Canonical abstraction is a static analysis technique that represents states as 3-valued logical structures, and is able to construct finite representations of systems with infinite statespaces for verification.
Groves, Lindsay, Friggens, David
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Reasoning by Analogy via Abstraction
, 1995 ion has been used in theorem proving as an heuristic to reduce the search space and as a tool for explanation. We use abstraction to model certain forms of reasoning by analogy.
Villafiorita Monteleone, Adolfo
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Abstract abstracts and other abstractions [PDF]
The Journal of Wildlife Management, 2016 Paul R. Krausman +2 more
openaire +1 more source
, 2019 The paper looks at abstract meaning or references in comics to understand better the limitations for comics’ storytelling that might result from using higher forms of abstraction.
Dittmar, Jakob
core
Abstraction and invariance for algebraically indexed types
, 2013 Reynolds’ relational parametricity provides a powerful way to rea- son about programs in terms of invariance under changes of data representation.
Kennedy, Andrew +5 more
core +1 more source
KELAM DİLİNİN KURGUSAL NİTELİĞİ-Din-Kelam İlişkisi ve Kelamda Kavramsal Soyutlamanın Zorunluluğu-
İslami İlimler Dergisi, 2009 A comparision between the religion and kalam from the viewpoint of nature and aim procures to form an opinion about the apperance of kalam and its function which it realized throughout its own history.
Galip Türcan
doaj