Results 121 to 130 of about 213,552 (301)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Abstraction and non-sequitur [Elektronisk resurs]
, 2019 The paper looks at abstract meaning or references in comics to understand better the limitations for comics’ storytelling that might result from using higher forms of abstraction.
Dittmar, Jakob,
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Levellism and the Method of Abstraction by
, 2008 The use of “levels of abstraction ” in philosophical analysis (levellism) has recently come under attack. In this paper, we argue that a refined version of epistemological levellism should be retained as a fundamental method, which we call the method of ...
The Method Of Abstraction +1 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
L’art abstrait du xxe siècle, autour de l’arabesque
Perspective, 2010 Markus Brüderlin
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Abstraction-based satisfiability solving of Presburger arithmetic
, 2018 : "We present a new abstraction-based framework for deciding satisfiability of quantifier-free Presburger arithmetic formulas. Given a Presburger formula [phi], our algorithm invokes a SAT solver to produce proofs of unsatisfiability of approximations of
Daniel Kroening (5407820)
core +1 more source
Associate/Dissociate: Allusive and Elusive Care in Veronica Ryan’s Sculpture
ArtsReflecting on the experience of curating Veronica Ryan’s work for the 2021 exhibition Life Support: Forms of Care in Art and Activism at Glasgow Women’s Library, this essay contextualizes the artist’s recent sculptures in relation to the theories ...
Catherine Spencer
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source