Results 161 to 170 of about 3,683,011 (357)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Interstellar Glycolaldehyde, Methyl Formate, and Acetic Acid. I. A Bimodal Abundance Pattern in Star-forming Regions [PDF]

, 2019
Samer J. El-Abd, Crystal L. Brogan, Todd R. Hunter, Eric R. Willis, Robin T. Garrod, Brett A. McGuire   +5 more
openalex   +1 more source

Wetland characteristics affect abundance and diversity of wintering birds: A case study in South‐Western Iran

, 2022
Mansoureh Malekian, Roghayeh Salarpour, Mehrdad Ranaie   +2 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Exploring Suitable Nitrification Inhibitor in an Intensively Cultivated Greenhouse Soil and Its Effect on the Abundance and Community of Soil Ammonia Oxidizers

Agronomy
The application of nitrification inhibitors (NIs) is an effective way to reduce soil nitrogen (N) losses and increase crop N uptake. Yet, the efficacy of NIs commonly varies with dosages, crop systems and soil environmental conditions.
Xing Liu, Yanan Cheng, Ying Zhang, Fei Wang, Yonggang Li, Changwei Shen, Bihua Chen   +6 more
doaj   +1 more source

Glycogen Synthase Kinase 3-Dependent Phosphorylation of Mdm2 Regulates p53 Abundance

, 2005
R. Kulikov, Karen A. Boehme, Christine Blattner   +2 more
openalex   +1 more source

Ortho-to-para abundance ratios of NH₂in 26 comets: implications for the real meaning of OPRs [PDF]

, 2016
Yoshiharu Shinnaka, Hideyo Kawakita, Emmanuël Jehin, Alice Decock, Damien Hutsemékers, Jean Manfroid   +5 more
openalex   +1 more source