Results 121 to 130 of about 485,382 (284)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Assessing the suitability of a one‐time sampling event for close‐kin mark‐recapture: A caribou case study

Ecology and Evolution
Abundance estimation is frequently an objective of conservation and monitoring initiatives for threatened and other managed populations. While abundance estimation via capture–mark–recapture or spatially explicit capture–recapture is now common, such ...
Brandon D. Merriell, Micheline Manseau, Paul J. Wilson   +2 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Low levels of sibship encourage use of larvae in western Atlantic bluefin tuna abundance estimation by close-kin mark-recapture. [PDF]

Sci Rep, 2022
McDowell JR, Bravington M, Grewe PM, Lauretta M, Walter JF, Baylis SM, Gosselin T, Malca E, Gerard T, Shiroza A, Lamkin JT, Biesack EE, Zapfe G, Ingram W, Davies C, Porch C.   +15 more
europepmc   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Estimating Demographic Parameters for Bearded Seals, Erignathus barbatus, in Alaska Using Close‐Kin Mark‐Recapture Methods

Evolutionary Applications
Reliable estimates of population abundance and demographics are essential for managing harvested species. Ice‐associated phocids, “ice seals,” are a vital resource for subsistence‐dependent coastal Native communities in western and northern Alaska, USA ...
Brian D. Taras, Paul B. Conn, Mark V. Bravington, Andrzej Kilian, Aimée R. Lang, Anna Bryan, Raphaela Stimmelmayr, Lori Quakenbush   +7 more
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Abundance estimation for line transect sampling: A comparison of distance sampling and spatial capture-recapture models. [PDF]

PLoS One, 2021
Crum NJ, Neyman LC, Gowan TA.
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Bellwethers of change: population modelling of North Pacific humpback whales from 2002 through 2021 reveals shift from recovery to climate response

Royal Society Open Science
For the 40 years after the end of commercial whaling in 1976, humpback whale populations in the North Pacific Ocean exhibited a prolonged period of recovery.
Ted Cheeseman, Jay Barlow, Jo Marie Acebes, Katherina Audley, Lars Bejder, Caitlin Birdsall, Olga Solis Bracamontes, Amanda L. Bradford, Josie Byington, John Calambokidis, Rachel Cartwright, Jen Cedarleaf, Andrea Jacqueline García Chavez, Jens Currie, Rouenne Camille De Castro, Joëlle De Weerdt, Nicole Doe, Thomas Doniol-Valcroze, Karina Dracott, Olga Filatova, Rachel Finn, Kiirsten R. Flynn, John Ford, Astrid Frisch-Jordán, Chris Gabriele, Beth Goodwin, Craig Hayslip, Jackie Hildering, Marie C. Hill, Jeff K. Jacobsen, M. Esther Jiménez-López, Meagan Jones, Nozomi Kobayashi, Marc Lammers, Edward Lyman, Mark Malleson, Evgeny Mamaev, Pamela Martínez Loustalot, Annie Masterman, Craig O. Matkin, Christie McMillan, Jeff Moore, John Moran, Janet L. Neilson, Hayley Newell, Haruna Okabe, Marilia Olio, Christian D. Ortega-Ortiz, Adam A. Pack, Daniel M. Palacios, Heidi Pearson, Ester Quintana-Rizzo, Raul Ramírez Barragán, Nicola Ransome, Hiram Rosales-Nanduca, Fred Sharpe, Tasli Shaw, Ken Southerland, Stephanie Stack, Iain Staniland, Janice Straley, Andrew Szabo, Suzie Teerlink, Olga Titova, Jorge Urban-Ramirez, Martin van Aswegen, Marcel Vinicius, Olga von Ziegesar, Briana Witteveen, Janie Wray, Kymberly Yano, Igor Yegin, Denny Zwiefelhofer, Phil Clapham   +73 more
doaj   +1 more source