Results 141 to 150 of about 123,013 (299)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Estimating Abundance from Presence-Absence Maps Using Kernel Density Estimation

, 2013
This research is intended to apply spatial statistical approaches to estimate species abundance from presence-absence maps. Several methods have been developed to solve this problem, but most of them do not take account of spatial dependence.
Chang, Ya-Mei; 張雅梅
core  

Inter-annual and seasonal trends in cetacean distribution, density and abundance off southern California

, 2015
Funding was provided by the Chief of Naval Operations Environmental Readiness Division, the United States Navy’s Pacific Fleet, the Naval Postgraduate School Grant #N00244-11-1-027, and the Naval Facilities Engineering Command Living Marine Resources ...
Whitaker, K., Douglas, Annie B., Campbell, G.S., Calambokidis, John, Thomas, L., Campbell, Gregory S., Calambokidis, J., Calambokidis, J, Douglas, AB, Campbell, GS, Douglas, A.B., Hildebrand, J.A., Hildebrand, John A., Hildebrand, JA, Thomas, L, Whitaker, K, Whitaker, Katherine, Thomas, Len   +17 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Estimation of species abundance on presence-absence maps with kernel density estimation method

, 2018
碩士在生態學中，為了維護及保育物種，知曉物種數量是相當重要的過程，而估計物種數量的方法中，使用有無地圖又是較節省成本及方便的估計方式。本篇運用核估計，並單純只使用有無地圖來估計物種的豐富度，並與之前提及的估計方法，比較是否能改善估計出來的結果。在第三章中，本篇使用R軟體套件，搭配不同的標準差去模擬生物在實際區域的分布行為，而第四章中，本篇使用一座巴拿馬的實際小島資料去進行物種豐富度的分析，在模擬及實例分析下，探討使用核估計法來估計物種豐富度，並與隨機放置模型、HG 方法和修正 HG 方法 ...
黃纓綺;Huang, Ying-Chi
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Cetacean studies using platforms of opportunity

, 2012
Chapters 1-5 of this thesis have been updated and subsequently published in multi-authored articles in peer-reviewed journals. If required, citations should be made to these updated articles listed in the full item record belowAs human impact on marine ...
Williams, Rob
core  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Accurate genome relative abundance estimation based on shotgun metagenomic reads.

, 2011
Accurate estimation of microbial community composition based on metagenomic sequencing data is fundamental for subsequent metagenomics analysis. Prevalent estimation methods are mainly based on directly summarizing alignment results or its variants ...
Jed A Fuhrman, Ting Chen, Jacob A Cram, Xia Li C., Fuhrman Jed A., Jacob A. Cram, Sun Fengzhu, Fengzhu Sun, Jed A. Fuhrman, Li C Xia, Chen Ting, Cram Jacob A., Li C. Xia   +12 more
core   +1 more source

Zein‐Based Adhesives: Sustainable Extraction and Application in Bioadhesive Technologies

Advanced Engineering Materials, EarlyView.
Zein is extracted from corn gluten meal using a simple and scalable process with high yield (~90%). The resulting protein is applied in bioadhesives modified with Ca2+ and Fe3+ ions, exhibiting substrate‐dependent adhesion. The findings demonstrate competitive bonding performance and highlight the role of ionic interactions in tuning adhesion ...
Paula Bertolino Sanvezzo, Daniela Winsley Valereto Friozi, Vinícius de Oliveira, Marcia Cristina Branciforti   +3 more
wiley   +1 more source