Results 71 to 80 of about 485,382 (284)

Estimating the abundance of the critically endangered Baltic Proper harbour porpoise (Phocoena phocoena) population using passive acoustic monitoring

open access: yesEcology and Evolution, 2022
Knowing the abundance of a population is a crucial component to assess its conservation status and develop effective conservation plans. For most cetaceans, abundance estimation is difficult given their cryptic and mobile nature, especially when the ...
Mats Amundin   +32 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Using satellite imagery to estimate abundance of Cumberland Sound beluga whales (Delphinapterus leucas) in 2021

open access: yesFrontiers in Marine Science
The Cumberland Sound beluga whale (Delphinapterus leucas) population inhabits Cumberland Sound on the southeast side of Baffin Island, Nunavut. The population is listed as threatened under the Species at Risk Act.
Bryanna A. H. Sherbo   +5 more
doaj   +1 more source

The mass-metallicity relation of local active galaxies

open access: yes, 2019
We systematically measure the gas-phase metallicities and the mass-metallicity relation of a large sample of local active galaxies for the first time.
Dopita, Michael A.   +5 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Distributed Unmixing of Hyperspectral Data With Sparsity Constraint

open access: yes, 2017
Spectral unmixing (SU) is a data processing problem in hyperspectral remote sensing. The significant challenge in the SU problem is how to identify endmembers and their weights, accurately. For estimation of signature and fractional abundance matrices in
Khoshsokhan, Sara   +2 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Hybrid mark–resight approaches account for heterogeneous detection bias in aerial surveys

open access: yesEcological Solutions and Evidence, 2023
Population abundance estimation is a critical yet challenging task for wildlife management decision‐making. For aerial surveys of terrestrial mammals in highly heterogenous landscapes, estimation models that address multiple sources of detection bias are
Kylie M. Curtis   +6 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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