Results 71 to 80 of about 123,013 (299)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Global coverage of cetacean line-transect surveys : status quo, data gaps and future challenges
, 2012 Knowledge of abundance, trends and distribution of cetacean populations is needed to inform marine conservation efforts, ecosystem models and spatial planning.
Catriona M Harris +19 more
core +1 more source
Ecology and Evolution, 2022 Knowing the abundance of a population is a crucial component to assess its conservation status and develop effective conservation plans. For most cetaceans, abundance estimation is difficult given their cryptic and mobile nature, especially when the ...
Mats Amundin +32 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Frontiers in Marine ScienceThe Cumberland Sound beluga whale (Delphinapterus leucas) population inhabits Cumberland Sound on the southeast side of Baffin Island, Nunavut. The population is listed as threatened under the Species at Risk Act.
Bryanna A. H. Sherbo +5 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Estimating bird abundance : making methods work
, 2008 In many bird monitoring Surveys, no attempt is made to estimate bird densities or abundance. instead, counts of one form or another are made, and these are assumed to correlate with bird density. Unless complete Counts Oil Sample plots are feasible, this
Marsden, Stuart J. +2 more
core +1 more source
Hybrid mark–resight approaches account for heterogeneous detection bias in aerial surveys
Ecological Solutions and Evidence, 2023 Population abundance estimation is a critical yet challenging task for wildlife management decision‐making. For aerial surveys of terrestrial mammals in highly heterogenous landscapes, estimation models that address multiple sources of detection bias are
Kylie M. Curtis +6 more
doaj +1 more source