Results 111 to 120 of about 1,003,844 (306)

Violent mergers revisited: The origin of the fastest stars in the Galaxy

Astronomy & Astrophysics
Binary systems of two carbon-oxygen white dwarfs are one of the most promising candidates for the progenitor systems of Type Ia supernovae. Violent mergers, where the primary white dwarf ignites when the secondary white dwarf smashes into it while being ...
Pakmor Rüdiger, Shen Ken J., Bhat Aakash, Rajamuthukumar Abinaya Swaruba, Collins Christine E., O’Donnell Cillian, Bauer Evan B., Callan Fionntan P., Röpke Friedrich K., Pollin Joshua M., Maguire Kate, Kwok Lindsey A., Seth Ravi, Taubenberger Stefan, Justham Stephen   +14 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Impact of in situ nuclear networks and atomic opacities on neutron star merger ejecta dynamics, nucleosynthesis, and kilonovae

Astronomy & Astrophysics
Context. Binary neutron star merger (BNSM) ejecta are key sites of rapid neutron capture (r-process) nucleosynthesis and they produce kilonovae powered by the radioactive decay of freshly synthesized nuclei.
Magistrelli Fabio, Bernuzzi Sebastiano, Perego Albino, Jacobi Maximilian, Fontes Christopher J.   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Novae breves from magnetar giant flares: Potential probes of neutron star crusts

Astronomy & Astrophysics
Context. Matter ejected from the magnetar crust during giant flares (GFs) may undergo r-process nucleosynthesis, producing short-lived optical transients termed “novae breves”.
Zhong Jiahang, Chen Qiu-Hong, Kang Yacheng, Li Hong-Bo, Zhang Jinghao, Chen Meng-Hua, Shao Lijing   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Direct determination of the astrophysical reaction rate of 141Pr(γ, n)140Pr at the SSRF-SLEGS

Astronomy & Astrophysics
Context. The 141Pr(γ, n) cross-section is critical to the nucleosynthesis of p-nuclides 136,138Ce in thermonuclear supernovae and in massive stars. The photonuclear reaction of 141Pr(γ, n) provides a new method for producing 140Pr radioisotopes for ...
Hu J. H., An Z. D., Hao Z. R., Li Z. C., Fan G. T., Wang H. W., Ma Y. G., Liu T., Liang H., Wen H. H., Guo C. C.   +10 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Probing millisecond magnetar formation in binary neutron star mergers through X-ray follow-up of gravitational wave alerts

Astronomy & Astrophysics
Context. The nature of the remnant of a binary neutron star (BNS) merger is uncertain. Although it certainly is a black hole in the cases of the most massive BNSs, X-ray light-curves from short gamma-ray burst afterglows suggest a neutron star (NS) as a ...
Plasse C., Reboul-Salze A., Guilet J., Götz D., Leroy N., Raynaud R., Bugli M., Dal Canton T.   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source