Results 91 to 100 of about 627,744 (337)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Novae breves from magnetar giant flares: Potential probes of neutron star crusts

Astronomy & Astrophysics
Context. Matter ejected from the magnetar crust during giant flares (GFs) may undergo r-process nucleosynthesis, producing short-lived optical transients termed “novae breves”.
Zhong Jiahang, Chen Qiu-Hong, Kang Yacheng, Li Hong-Bo, Zhang Jinghao, Chen Meng-Hua, Shao Lijing   +6 more
doaj   +1 more source

Beryllium anomalies in solar-type field stars

, 2004
We present a study of beryllium (Be) abundances in a large sample of field solar-type dwarfs and sub-giants spanning a large range of effective temperatures.
Allende Prieto, Anders, Balachandram, Barnes, Boesgaard, Boesgaard, Boesgaard, Boesgaard, Boesgaard, Chen, Chmielewski, Da Silva, Deliyannis, Deliyannis, Deliyannis, G. Israelian, García López, García López, García López, Gonzalez, Gonzalez, Gonzalez, Grevesse, Henry, Huensch, Israelian, Israelian, Jones, Molaro, Montalban, Murray, N. C. Santos, Naef, Pasquini, Pasquini, Pinsonneault, Primas, Quillen, R. J. García López, R. Rebolo, Ramaty, Randich, Randich, Randich, Rebolo, Reeves, Rocha-Pinto, S. Randich, Santos, Santos, Santos, Santos, Soderblom, Soderblom, Stephens, Swenson, Vaughan, Vaughan   +57 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fluorine abundances in planetary nebulae

, 2005
We have determined fluorine abundances from the F II 4789 and F IV 4060 nebular emission lines for a sample of planetary nebulae (PNe). Our results show that fluorine is generally overabundant in PNe, thus providing new evidence for the synthesis of ...
Butler K., Forestini M., Jorissen A., Lennon D. J., Meynet G., X.-W. Liu, Y. Zhang   +6 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Oxygen abundance distributions in six late-type galaxies based on SALT spectra of HII regions

, 2015
Spectra of 34 H II regions in the late-type galaxies NGC1087, NGC2967, NGC3023, NGC4030, NGC4123, and NGC4517A were observed with the South African Large Telescope (SALT). In all 34 H II regions, oxygen abundances were determined through the "counterpart"
Grebel, E. K., Kniazev, A. Y., Pilyugin, L. S., Zinchenko, I. A.   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Elemental Abundances in NGC 3516

, 2003
We present RGS data from an XMM-Newton observation of the Seyfert 1 galaxy NGC 3516, taken while the continuum source was in an extreme low state. The spectrum shows numerous emission lines including the H-like lines of C, N and O and the He-like lines ...
Gabel, J. R., George, I. M., Kraemer, S. B., Mushotzky, R. F., Turner, T. J.   +4 more
core   +1 more source

Dark Matter abundance via thermal decays and leptoquark mediators

, 2021
Benedetta Belfatto, Dario Buttazzo, Christian Groß, Paolo Panci, Алессандро Струмиа, Natascia Vignaroli, Ludovico Vittorio, Ryoutaro Watanabe   +7 more
openalex   +1 more source