Results 71 to 80 of about 204,301 (258)
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
The impact of the carbon fusion rate on the properties of superbursts
Astronomy & AstrophysicsContext. Superbursts are very energetic explosions in the crust of neutron stars in low-mass X-ray binaries (LMXBs). These are triggered by unstable carbon burning at T ≤ 109 K.
Nava-Callejas M., Goriely S., Chamel N.
doaj +1 more source
Nucleosynthesis Predictions and High-Precision Deuterium Measurements
Universe, 2017 Two new high-precision measurements of the deuterium abundance from absorbers along the line of sight to the quasar PKS1937–1009 were presented. The absorbers have lower neutral hydrogen column densities (N(HI) ≈ 18 cm − 2 ) than for previous ...
Signe Riemer-Sørensen +1 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Astronomy & AstrophysicsContext. The primordial 7Li abundance predicted by standard Big Bang nucleosynthesis (BBN) exceeds the value inferred from old metal-poor stars by a factor of approximately three to four. In this model, most primordial 7Li is produced as 7Be in the early
Taioli Simone +2 more
doaj +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
I-Process Nucleosynthesis in AM CVn Systems
GalaxiesWe investigate nucleosynthesis during very strong, non-dynamical recurrent He-flashes that are expected to occur in close binary systems hosting a carbon–oxygen white dwarf and a type-B subdwarf companion.
Luciano Piersanti +6 more
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Astronomy & AstrophysicsContext. The nature of the remnant of a binary neutron star (BNS) merger is uncertain. Although it certainly is a black hole in the cases of the most massive BNSs, X-ray light-curves from short gamma-ray burst afterglows suggest a neutron star (NS) as a ...
Plasse C. +7 more
doaj +1 more source