Results 131 to 140 of about 1,003,844 (306)

Generalized Te([O iii])–Te(He i) Discrepancies in Ionized Nebulae: Possible Evidence of Case B Deviations and Temperature Inhomogeneities

open access: yesThe Astrophysical Journal
The physics of recombination lines in the He i singlet system is expected to be relatively simple, supported by accurate atomic models. We examine the intensities of He i singlets λ 3614,  λ 3965,  λ 5016,  λ 6678, and  λ 7281 and the triplet He i λ 5876
J. E. Méndez-Delgado   +13 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

A Systematic NLTE Study of Very Metal-poor Stars with Metallicity down to −4.3 dex. I. Global Stellar Parameters Based on High-resolution Spectra

open access: yesThe Astrophysical Journal
Very metal-poor (VMP) stars provide a record of the chemical composition and dynamics of the early Galaxy. Based on the high-resolution and high signal-to-noise ratio spectra from the Subaru Telescope for 103 VMP stars, in this series of papers we ...
Jianrong Shi   +12 more
doaj   +1 more source

Gaia-Sausage-Enceladus: Lithium evolution from early red-giant-branch and main-sequence stars

open access: yesAstronomy & Astrophysics
The combination of data from the Gaia satellite and large ground-based spectroscopic surveys recently led to a milestone understanding of our Galaxy’s formation history, marked by the identification of stellar remnants of the accreted Gaia-Sausage ...
Nguyen C. T.   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

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