Results 131 to 140 of about 195,329 (258)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

16 years of gelatinous zooplankton seasonal abundances reveal food availability and temperature as key drivers in Arctic latitudes. [PDF]

Sci Rep
Detsch CWG, Juul-Pedersen T, Verhaegen G, Havermans C, Kohlbach D.   +4 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Dietary 4-Hydroxy-2,5-Dimethyl-3(2H)-Furanone Supplementation in Hu Sheep: Implications on Fecal and Rumen Microbiota. [PDF]

Animals (Basel)
Liu C, Chen X, Fu C, Ouyang K, Qu M, Qiu Q.   +5 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

High early-life gut Bacteroides links to microbiome stability, resilience, and risk for childhood infections. [PDF]

NPJ Biofilms Microbiomes
Hauptmann M, Gottschick C, Muthukumarasamy U, Klee B, Strowig T, Mikolajczyk R, Schaible UE.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Chemical Components of Volatile Oils and Hydrosols Derived from Different Plant Organs of Three <i>Scutellaria</i> L. Species. [PDF]

Plants (Basel)
Rodideal T, Ciocârlan N, Ivănescu LC, Frunzete ME, Zamfirache MM, Ion VA, Bădulescu L.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Expansion of pathogens and restoration of human skin microbiome in CD4 T-cell lymphopenia. [PDF]

J Invest Dermatol
Han J, Lisco A, Che Y, Anderson MV, Laidlaw E, Kim CS, Hou P, Conlan S, Proctor DM, Lee-Lin S, Amirkhani A, Holmes CJ, Suh GS, Brownell I, NISC Comparative Sequencing Program, Segre JA, Sereti I, Kong HH.   +17 more
europepmc   +1 more source