Results 121 to 130 of about 612,500 (304)
The Astrophysical JournalThe element abundances of stars, particularly the refractory elements (e.g., Fe, Si, and Mg), play an important role in connecting stars to their planets. Most Sun-like stars do not have refractory abundance measurements since obtaining a large sample of
Rayna Rampalli +4 more
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The void abundance with non-gaussian primordial perturbations [PDF]
, 2009 Marc Kamionkowski +2 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11
The Astrophysical Journal LettersWe interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
The Astronomical JournalIn this study, we investigate interstellar absorption lines along the line of sight toward the galactic low-mass X-ray binary Cygnus X-2. We combine absorption line data obtained from high-resolution X-ray spectra collected with the Chandra and XMM ...
I. Psaradaki +12 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Hubble Constant Anchor Galaxy NGC 4258: Metallicity and Distance from Blue Supergiants
The Astrophysical JournalA quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [ Z ] =
Rolf-Peter Kudritzki +7 more
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Interstellar Glycolaldehyde, Methyl Formate, and Acetic Acid. I. A Bimodal Abundance Pattern in Star-forming Regions [PDF]
, 2019 Samer J. El-Abd +5 more
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