Results 131 to 140 of about 606,356 (317)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

The Sun Remains Relatively Refractory Depleted: Elemental Abundances for 17,412 Gaia RVS Solar Analogs and 50 Planet Hosts

The Astrophysical Journal
The element abundances of stars, particularly the refractory elements (e.g., Fe, Si, and Mg), play an important role in connecting stars to their planets. Most Sun-like stars do not have refractory abundance measurements since obtaining a large sample of
Rayna Rampalli, Melissa K. Ness, Graham H. Edwards, Elisabeth R. Newton, Megan Bedell   +4 more
doaj   +1 more source

Deriving Amorphous Component Abundance and Composition of Rocks and Sediments on Earth and Mars [PDF]

, 2018
R. J. Smith, E. B. Rampe, B. Horgan, E. Dehouck   +3 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Rapid Chemical Enrichment by Intermittent Star Formation in GN-z11

The Astrophysical Journal Letters
We interpret the peculiar supersolar nitrogen abundance recently reported by the James Webb Space Telescope observations for GN-z11 ( z = 10.6) using our state-of-the-art chemical evolution models.
Chiaki Kobayashi, Andrea Ferrara
doaj   +1 more source

Maternal supply of methionine during late pregnancy is associated with changes in immune function and abundance of microRNA and mRNA in Holstein calf polymorphonuclear leukocytes [PDF]

, 2018
Carolina Bespalhok Jacometo, Abdulrahman S. Alharthi, Zheng Zhou, D. Luchini, Juan J. Loor   +4 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Elemental Abundances in the Diffuse Interstellar Medium from Joint Far-ultraviolet and X-Ray Spectroscopy: Iron, Oxygen, Carbon, and Sulfur

The Astronomical Journal
In this study, we investigate interstellar absorption lines along the line of sight toward the galactic low-mass X-ray binary Cygnus X-2. We combine absorption line data obtained from high-resolution X-ray spectra collected with the Chandra and XMM ...
I. Psaradaki, L. Corrales, J. Werk, A. G. Jensen, E. Costantini, M. Mehdipour, R. Cilley, N. Schulz, J. Kaastra, J. A. García, L. Valencic, T. Kallman, F. Paerels   +12 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Hubble Constant Anchor Galaxy NGC 4258: Metallicity and Distance from Blue Supergiants

The Astrophysical Journal
A quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [ Z ] =
Rolf-Peter Kudritzki, Miguel A. Urbaneja, Fabio Bresolin, Lucas M. Macri, Wenlong Yuan, Siyang Li, Gagandeep S. Anand, Adam G. Riess   +7 more
doaj   +1 more source