Results 131 to 140 of about 1,234,720 (380)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Coronae of Stars with Super Solar Elemental Abundances

, 2015
Coronal elemental abundances are known to deviate from the photospheric values of their parent star, with the degree of deviation depending on the First Ionization Potential (FIP).
Behar, Ehud, Drake, Stephen A., Peretz, Uria   +2 more
core   +1 more source

Chemical abundances of 1111 FGK stars from the HARPS GTO planet search program - Galactic stellar populations and planets [PDF]

, 2012
Context. We performed a uniform and detailed abundance analysis of 12 refractory elements (Na, Mg, Al, Si, Ca, Ti, Cr, Ni, Co, Sc, Mn, and V) for a sample of 1111 FGK dwarf stars from the HARPS GTO planet search program.
V. Adibekyan, S. Sousa, S. Sousa, N. Santos, E. D. Mena, J. Hernández, J. Hernández, G. Israelian, G. Israelian, M. Mayor, G. Khachatryan   +10 more
semanticscholar   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Co-spatial Long-slit UV/Optical Spectra of Ten Galactic Planetary Nebulae with HST/STIS I. Description of the Observations, Global Emission-line Measurements, and CNO Abundances

, 2015
We present observations and initial analysis from an HST/STIS program to obtain the first co-spatial, UV-optical spectra of ten Galactic planetary nebulae (PNe). Our primary objective was to measure the critical emission lines of carbon and nitrogen with
Balick, Bruce, Corradi, Romano L. M., Dufour, Reginald J., Henry, Richard B. C., Kwitter, Karen B., Shaw, Richard A.   +5 more
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Lithium abundances in CEMP stars

, 2012
Carbon-enhanced metal-poor (CEMP) stars are believed to show the chemical imprints of more massive stars (M > 0.8 Msun) that are now extinct. In particular, it is expected that the observed abundance of Li should deviate in these stars from the standard ...
Abia, Alvarez, Amanda Karakas, Aoki, Aoki, Aoki, Aoki, Aoki, Aoki, Aoki, Asplund, Asplund, Bertrand Plez, Christlieb, Cohen, Cristallo, Denissenkov, Denissenkov, Eggleton, Frebel, Goriely, Herwig, Hobbs, Iwamoto, Jennifer A. Johnson, Johnson, Johnson, Karakas, Lawler, Lucatello, Lucatello, Lucatello, Lucatello, Lucatello, Masseron, Nollett, Norbert Christlieb, Norris, Norris, Norris, Norris, Palmerini, Preston, Richard, Roederer, Ryan, Ryan, Sara Lucatello, Siess, Sneden, Spite, Spite, Steffen, Suda, Suda, Thomas Masseron, Thompson, Thorburn, Timothy C. Beers, Tsangarides, VandenBerg   +60 more
core   +3 more sources

STELLAR CHEMICAL ABUNDANCES: IN PURSUIT OF THE HIGHEST ACHIEVABLE PRECISION [PDF]

, 2014
The achievable level of precision on photospheric abundances of stars is a major limiting factor on investigations of exoplanet host star characteristics, the chemical histories of star clusters, and the evolution of the Milky Way and other galaxies ...
M. Bedell, J. Meléndez, J. Bean, I. Ramírez, P. Leite, M. Asplund   +5 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source