Results 141 to 150 of about 612,500 (304)

Comparison of Abundance of Premolar and Molar Pulp Stones Before and After Orthodontic Treatment Using Panoramic Radiography

, 2021
Erfaneh Afsari, Elmira Niksolat, Farzaneh Ostovar, Shaghayegh Karimi   +3 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Abundances of Planetary Nebulae and Evolved Stars: Iron and Sulfur Depletion, and Carbon and Nitrogen Enrichment, in Low- and Intermediate-mass Stellar Populations in the Milky Way

The Astrophysical Journal
We research the elemental abundances in Galactic planetary nebulae (PNe) compared with those of their stellar progenitors (red giant branch and asymptotic giant branch, AGB, stars), to explore and quantify the expected—i.e., due to AGB evolution or ...
Letizia Stanghellini, Verne V. Smith, Katia Cunha, Nikos Prantzos   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Isotopic Compositions and Elemental Abundances of Chromium in Presolar Silicon Carbide Grains from Asymptotic Giant Branch Stars

The Astrophysical Journal
Isotopes of chromium (Cr) and other iron-group elements are predominantly made in the inner shells of supernovae and are later reprocessed via the slow neutron capture process ( s -process) in asymptotic giant branch (AGB) stars.
Kuljeet K. Marhas, Manish N. Sanghani, Scott R. Messenger, Antariksha Mitra, Ritesh K. Mishra   +4 more
doaj   +1 more source

Using mobile acoustic monitoring and false‐positive N‐mixture models to estimate bat abundance and population trends [PDF]

Bradley J. Udell, Bethany Straw, Susan C. Loeb, Kathryn M. Irvine, Wayne E. Thogmartin, Cori L. Lausen, Jonathan D. Reichard, Jeremy T. H. Coleman, Paul M. Cryan, Winifred F. Frick, Brian E. Reichert   +10 more
openalex   +1 more source

Human colonic in vitro fermentation of water-soluble arabinoxylans from hard and soft wheat alters Bifidobacterium abundance and short-chain fatty acids concentration

, 2020
Candela Paesani, Lorena S. Sciarini, Malena Moiraghi, Emiliano Salvucci, Samira Bernardino Ramos do Prado, Gabriela Pérez, João Paulo Fabi   +6 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Demography of the Intertidal Fucoid Hormosira banksii: Importance of Recruitment to Local Abundance

, 2021
Ryan D. Lewis, Craig R. Johnson, Jeffrey T. Wright   +2 more
openalex   +2 more sources