Results 71 to 80 of about 464,371 (256)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Understanding the various evolutionary stages of the low-mass star-formation process by SO and SO2

open access: yesFrontiers in Astronomy and Space Sciences
SO and SO2 are two potential candidates to trace the different evolutionary phases of the low-mass star-formation process. Here, we report observations of SO and SO2 along with their isotopologues, 34SO and 34SO2, respectively, in four distinct phases of
Rana Ghosh   +10 more
doaj   +1 more source

The Metallicity and Distance of Leo A from Blue Supergiants

open access: yesThe Astrophysical Journal, 2023
We have obtained high-quality spectra of blue supergiant candidates in the dwarf irregular galaxy Leo A with the Low Resolution Imaging Spectrometer at the Keck I telescope.
Miguel A. Urbaneja   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Selecting a Photometric System for Gaia: C, N, O and Alpha-Process Elements

open access: yesOpen Astronomy, 2003
The sensitivity of stellar spectra to C, N, O and α-process element abundances is discussed with the aim of taking this effect into account when selecting a photometric system for the Gaia orbiting observatory.
Tautvaišienė G.   +2 more
doaj   +1 more source

How Clumpy Star Formation Affects Globular Cluster Systems

open access: yesGalaxies, 2017
There is now clear evidence the metallicities of globular clusters are not simple tracers of the elemental abundances in their protocluster clouds; some of the heavy elements were formed subsequently within the cluster itself. It is also manifestly clear
Jeremy Bailin
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Slowly Rotating Peculiar Star BD00°1659 as a Benchmark for Stratification Studies in Ap/Bp Stars

open access: yesGalaxies
We present the results of a self-consistent analysis of the magnetic silicon star BD+00°1659, based on its high-resolution spectra taken from the ESPaDOnS archive (R = 68,000).
Anna Romanovskaya   +4 more
doaj   +1 more source

Measuring 14 elemental abundances with R=1,800 LAMOST spectra [PDF]

open access: yes, 2017
The LAMOST survey has acquired low-resolution spectra (R=1,800) for 5 million stars across the Milky Way, far more than any current stellar survey at a corresponding or higher spectral resolution.
Conroy, Charlie   +4 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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