Results 101 to 110 of about 1,169,779 (313)

Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study.

open access: yesAmerican Journal of Preventive Medicine, 1998
V. Felitti   +7 more
semanticscholar   +1 more source

Advances in Safe, Flexible, and Stretchable Batteries for Wearable Applications

open access: yesAdvanced Materials Technologies, EarlyView.
Unlike previous reviews centered on component‐based deformability, this work highlights safety‐driven design strategies for flexible and stretchable batteries. By integrating material‐level engineering, geometry‐controlled structures, biocompatibility, and self‐protection mechanisms, it establishes a unified framework that connects mechanical ...
Hyewon Kang   +4 more
wiley   +1 more source

Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain

open access: yesScientific Reports
[11C]Carfentanil ([11C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs).
Andrew C. Kelleher   +17 more
doaj   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

open access: yesAdvanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang   +51 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

open access: yesAdvanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang   +16 more
wiley   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

open access: yesAdvanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun   +15 more
wiley   +1 more source

Author Correction: Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence

open access: yesScientific Reports, 2021
Mary Tresa Zanda   +2 more
doaj   +1 more source

VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior

open access: yesNature Communications
The ventral tegmental area (VTA) dopamine neurons have been implicated in diverse behaviors. These VTAdopamine neurons are intermixed with neurons that co-transmit glutamate and GABA (VTAglutamate-GABA), transmit glutamate (VTAglutamate-only) or GABA ...
M. Flavia Barbano   +9 more
doaj   +1 more source

Hepatocyte‐Derived Extracellular Vesicles Deliver miR‐328‐3p to Trigger PP2A‐B56δ–Mediated p‐NLRP3S295‐Dependent Metaflammation in Macrophages upon Microcystin‐LR Exposure

open access: yesAdvanced Science, EarlyView.
Hepatocyte‐derived extracellular vesicles deliver miR‐328‐3p to trigger PP2A‐B56δ–mediated p‐NLRP3S295‐dependent metaflammation in macrophages upon microcystin‐LR exposure. 2‐DG, 2‐deoxy‐D‐glucose. B56δ, protein phosphatase 2A‐B56δ. ER, endoplasmic reticulum. iHD‐EV, inducible hepatocyte‐derived extracellular vesicles. IP3R, inositol 1,4,5‐triphosphate
Jia‐Shen Wu   +13 more
wiley   +1 more source

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