Results 21 to 30 of about 1,169,779 (313)
Frontiers in Psychiatry, 2019 Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and
Jamie A. Burns +8 more
doaj +1 more source
Drug-associated cues and drug dosage contribute to increased opioid seeking after abstinence
Scientific Reports, 2021 Patients with opioid use disorder experience high rates of relapse during recovery, despite successful completion of rehabilitation programs. A key factor contributing to this problem is the long-lasting nature of drug-seeking behavior associated with ...
Mary Tresa Zanda +2 more
doaj +1 more source
Trend in alcohol use in Australia over 13 years: has there been a trend reversal?
BMC Public Health, 2016 Background Skog’s collectivity theory of alcohol consumption predicted that changes in alcohol consumption would synchronize across all types of drinkers in a population. The aim of this paper is examine this theory in the Australian context. We examined
Gary C.K. Chan +9 more
doaj +1 more source
Long-term Cognitive, Psychological, and Health Outcomes Associated With Child Abuse and Neglect
Pediatrics, 2020 In this article, we integrate findings from the MUSP, a 2-decade longitudinal study assessing outcomes associated with different subtypes of child maltreatment.
Lane Strathearn +5 more
semanticscholar +1 more source
Hepatitis Infection in the Treatment of Opioid Dependence and Abuse
Substance Abuse: Research and Treatment, 2008 Many new and existing cases of viral hepatitis infections are related to injection drug use. Transmission of these infections can result directly from the use of injection equipment that is contaminated with blood containing the hepatitis B or C virus or
Thomas F. Kresina +6 more
doaj +1 more source
4191 The Role of Suggestibility and Trait Anxiety in Young Adult Alcohol Use
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: The purpose of this study was to investigate how suggestibility and social susceptibility relate to alcohol use in young adult non-dependent alcohol users, and the role of trait anxiety in this relationship. We hypothesized that greater
Alexandra Cowand +6 more
doaj +1 more source
Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training.
New England Journal of Medicine, 2019 BACKGROUND Physicians, particularly trainees and those in surgical subspecialties, are at risk for burnout. Mistreatment (i.e., discrimination, verbal or physical abuse, and sexual harassment) may contribute to burnout and suicidal thoughts.
Yue-Yung Hu +10 more
semanticscholar +1 more source
Cholesterol as a modulator of cannabinoid receptor CB2 signaling
Scientific Reports, 2021 Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev +7 more
doaj +1 more source
Language models in digital psychiatry: challenges with simplification of healthcare materials
NPP-Digital Psychiatry and NeuroscienceLinguistic hurdles in healthcare, such as complex language, significantly affect patient outcomes, including satisfaction with interaction, comprehension of healthcare materials, and engagement with the healthcare system.
Ankit Aich +6 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source