Results 21 to 30 of about 15,769 (255)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Revista de Literatura, 2012 Las primeras academias de ocasión impresas en Granada se publicaron entre 1661 y 1664. Por esos años, el concepto de academia aparece en dos pliegos relativos a fiestas granadinas para reforzar la cohesión de poemas escritos para las celebraciones.
Inmaculada Osuna
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Homenaje de las Academias Nacionales, Argentina
, 1980 Moneda medalla de metal plateada de 78 mm diámetroOriginalFil: No especifica. No especifíca;ColorInscripción en Anverso “A su Fundador Juan de Garay 1580 1980”. Homenaje de las Academias Nacionales (Medicina, Ciencias Exactas Físicas y Naturales, Derecho,
No especifica
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Castilla: Estudios de LiteraturaEl trabajo intenta estudiar la relación que El curioso y sabio Alejandro, fiscal y juez de vidas ajenas (1634), de Salas Barbadillo, entabla con sus textos académicos de “El curioso”—novela intercalada en el El caballero puntual (1619)—, La casa del ...
Leonardo Coppola
doaj +1 more source
Edad de Oro, 2020 A través de tres discursos pronunciados en el marco de la Academia de los Nocturnos (Valencia, 1591-1594) y dedicados a aspectos socioculturales, retóricos y lingüísticos, el presente artículo pretende analizar la sociabilidad entre cortesana y urbana ...
Mechthild Albert
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source