Results 31 to 40 of about 105,367 (306)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

La La visión académica en «El curioso y sabio Alejandro, fiscal y juez de vidas ajenas»: Salas Barbadillo y la invectiva contra el mal gusto socio-literario de la época

open access: yesCastilla: Estudios de Literatura
El trabajo intenta estudiar la relación que El curioso y sabio Alejandro, fiscal y juez de vidas ajenas (1634), de Salas Barbadillo, entabla con sus textos académicos de “El curioso”—novela intercalada en el El caballero puntual (1619)—, La casa del ...
Leonardo Coppola
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

sociabilidad reflejada a través de los discursos de la Academia de los Nocturnos (Valencia, 1591-1594)

open access: yesEdad de Oro, 2020
A través de tres discursos pronunciados en el marco de la Academia de los Nocturnos (Valencia, 1591-1594) y dedicados a aspectos socioculturales, retóricos y lingüísticos, el presente artículo pretende analizar la sociabilidad entre cortesana y urbana ...
Mechthild Albert
doaj   +1 more source

La enseñanza de la Mineralogía y de la Petrología, con especial atención a las Escuelas de Minas [PDF]

open access: yes, 1992
Suponemos que los primeros estudios mineralógicos se realizan dentro de las Academias filosóficas, las Cátedras personales o gracias a la transmisión oral maestro-discípulo, sin que la Mineralogía sea una materia específica en ningún plan de estudios ...
Mata Perelló, José M.   +1 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Corte y academias literarias en la España de Felipe IV [PDF]

open access: yes, 2012
This is a study of the Literary Academies that, under the protection of the Court, were celebrated in 17th century Spain under King Philip IV. We examine the way of organization of these cultural institutions in the Golden Age in Spain, its structure ...
Cañas Murillo, Jesús, 1951-
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

open access: yes
Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

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