Results 51 to 60 of about 2,064 (280)

Ableism/disablism, on dit ça comment en français? [PDF]

, 2017
Les concepts « ableism » et « disablism » sont bien connus dans les disability studies et sont de plus en plus utilisés par activistes et artistes. Pourtant, ils commencent à peine à émerger dans la littérature francophone.
Laurence Parent
core   +1 more source

Inequalities, barriers, intersectionality, and facilitators of careers of women with disabilities: Themes and future research agenda from a scoping review

Frontiers in Psychology, 2023
This article examines the career motivations, opportunities, and development of women with disabilities. The increasing number of women in paid work over recent decades has resulted in substantive research on all aspects of women’s careers, yet ...
Xi Wen Chan, Kate Hutchings
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Adverse Childhood Experiences of Disabled Children and Youth Resulting from Ableist Judgments and Disablist Treatments: A Scoping Review

Youth
Adverse childhood experiences (ACEs) are negative but preventable experiences within family and social environments. Originally focused on abuse and household dysfunction, ACE indicators now include many social factors, such as social determinants of ...
Gregor Wolbring, Parneet Dhindsa
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Ability expectations in collaborative research: Ethical reflections from three empirical studies with disability communities

Research Ethics Review
This study critically explores ability expectations in collaborative research with disability communities to highlight ethical consequences and outline an ableism-critical research practice.
Rahel More
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

From supercrip to techno supercrip

Current Issues in Sport Science
Participation in sport on all levels, physical activity, leisure and recreation is seen as important for disabled people but at the same time barriers are reported for disabled people.
Gregor Wolbring
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

“Te Kore and the Artiste within: De-Tyrannizing Autistic Viewpoints in Life, Self, and Identity through Creative Methodologies”

International Journal of Qualitative Methods, 2023
The voices of the autistic community have been systematically forfeited in research and practice, both as a consequence of the double empathy problem and, as a direct result of albeist methodic approaches to researching and representing autism (Milton ...
Michelle Whitehead
doaj   +1 more source