Results 91 to 100 of about 932,833 (298)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Exposing The Cancer Genome Atlas (TCGA) as a SPARQL endpoint [PDF]

open access: yes, 2011
Automated discovery of candidate biomarkers from multiple databases has been the central challenge in the Life Sciences in general and in the study of systemic processes such as those documented by The Cancer Genome Atlas (TCGA) in particular. &
Helena Deus
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Evidential adjectives in Lithuanian academic discourse

open access: yesKalbotyra, 2012
The present study explores the functional distribution of the neuter adjectives akivaizdu ‘evident, obvious’, aišku ‘clear’, natūralu ‘natural’ and panašu ‘likely’ in Lithuanian written academic discourse.
Anna Ruskan
doaj   +1 more source

Galileo's Revenge: ways of construing knowledge and translation strategies in the era of globalisation [PDF]

open access: yes, 2007
Galileo’s fateful confrontation with the Holy Office in 1633 is often taken to mark the start of the Scientific Revolution, the moment when a whole new approach to knowledge began to take over the western world.
Bennett, Karen
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Rhythmic Arrangement of English Academic Discourse

open access: yesArmenian Folia Anglistika, 2015
The article addresses the problem of the rhythmic arrangement of academic discourse and its main units. It is the result of computer-based acoustic investigation of English rhythm (in comparison with Armenian).
Lusine Vanyan
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

FOSTERING ACADEMIC LITERACY AND ACADEMIC WRITING IN UNIVERSITY: FROM THEORY TO PRACTICE

open access: yesВысшее образование в России, 2016
The paper addresses the theoretical and practical aspects of developing academic literacy of students. It overviews the nature and the structure of academic literacy and claims that academic literacy should be developed on the basis of academic discourse.
Natalia V. Smirnova
doaj  

Статистична верифікація соціолінгвістичної ідентифікації мовця в усному американському академічному дискурсі [PDF]

open access: yes, 2015
У статті розглядається питання соціолінгвістичної ідентифікації мовців в усному американському академічному дискурсі. Зокрема наводяться статистичні дані щодо вживання маркерів хеджингу як засобів ідентифікації та соціолінгвістичної характеристики ...
Жуковська, В. (V. Zhukovska)   +1 more
core  

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