Results 41 to 50 of about 108,861 (300)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The form and function of fixed collocational patterns in research articles in different academic disciplines [PDF]
, 2008 This thesis presents a comparative empirical study of fixed collocational patterns in written academic English. The fixed collocational pattern is a continuous string of words which is found to occur frequently in language data.
Oakey, David James
core
Вестник Северного (Арктического) федерального университета: Серия «Гуманитарные и социальные науки»Identifying the influence that the value system and cultural identity of a bilingual have on the use of the language system in academic communication is becoming increasingly important.
Olga S. Zubkova, Ilya G. Nikitichev
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Styl czy dyskurs naukowy? Perspektywa historyczna
Forum Lingwistyczne, 2018 Academic Style or Discourse? A Historical Perspective The work concerns the usefulness of terms “style” and “discourse” in research of academic Polish evolution.
Artur Rejter
doaj
Research impact evaluation and academic discourse
Humanities & Social Sciences Communications, 2021 The introduction of ‘impact’ as an element of assessment constitutes a major change in the construction of research evaluation systems. While various protocols of impact evaluation exist, the most articulated one was implemented as part of the British ...
Marta Natalia Wróblewska
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Evidential adjectives in Lithuanian academic discourse
Kalbotyra, 2012 The present study explores the functional distribution of the neuter adjectives akivaizdu ‘evident, obvious’, aišku ‘clear’, natūralu ‘natural’ and panašu ‘likely’ in Lithuanian written academic discourse.
Anna Ruskan
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source