Results 61 to 70 of about 108,861 (300)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Hybridisation in EU academic genres

open access: yes, 2011
This study is a quantitative qualitative analysis of EU academic discourse aiming at analysing the discursive representation of social actor(s), i.e. ‘the EU’ and EU citizens, particularly with reference to interdiscursivity, i.e.
S. D'AVANZO, POLESE, VANDA
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Writing as design: enabling access to academic discourse in a multimodal environment

open access: yes, 2012
This is an Accepted Manuscript of an article published by Taylor & Francis in South African Journal of Higher Education in 2012, available online: http://reference.sabinet.co.za/webx/access/electronic_journals/high/high_v26_n3_a2.pdf.This article builds ...
Archer, Arlene
core  

A corpus-based investigation of the phraseology in various genres of written English with applications to the teaching of English for academic purposes [PDF]

open access: yes, 2006
This thesis describes an investigation into the various kinds of fixed expressions or prefabricated language which occur in certain genres of written academic English. A basic premise is that language users, when they write, remember phrases as much as,
McKenny, John Anthony
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Educating for the future : a critical discourse analysis of the field of intercultural business communication [PDF]

open access: yes, 2007
The investigation analyzes critically the discursive and generic make-up, the conceptual base and educational goals of a new interdisciplinary academic field of enquiry called Intercultural Business Communication as it is pursued in the context of the ...
Zotzmann, Karin
core  

Discourse revisited : dimensions and employment of first-order strategy discourse during institutional adoption [PDF]

open access: yes, 2013
Despite decades of research on strategy, we still know little about what the concept of strategy means to actual strategists and how they use it in practice.
Paroutis, Sotirios   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Politeness strategies in academic digital discourse

open access: yes, 2012
The paper explores the discourse strategies used in academic discourse in the informal setting of a personal web page. The aim is to study a digital variation of academic discourse that blends features of spoken and written academic discourse.
Miššíková, Gabriela
core  

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