Results 61 to 70 of about 7,010,912 (334)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Math Remediation: How Repeatedly Failed Students Perceive The Remediation Program and Their Failures

IndoMath
Mathematics remediation (MR) is crucial in higher education, serving as a cornerstone to prepare under-equipped students. However, numerous Mathematics Education students in one of the public universities in Indonesia have repeatedly failed in this ...
Rustam Effendy Simamora, Jero Budi Darmayasa   +1 more
doaj   +1 more source

Explaining the causes and effective interventions in academic failure from the perspective of conditional students in Hamadan University of Medical Sciences: A qualitative study [PDF]

Journal of Medical Education and Development, 2023
Introduction: Due to the lack of information about the causes of academic failure of university students, as well as the lack of knowledge of effective interventions to prevent and reduce this problem, this qualitative study aims to explain the causes ...
ُSomaye Hashemi, Alireza Afsharian, Maryam Afshari, Fateme Zinati Daneshmand, Bahare Khademi Monfared   +4 more
doaj  

A Comparison of Parent and Teacher Ratings of Child Behaviours: the Pygmalion Effect Revisited [PDF]

, 2008
Early schooling experience is a reliable predictor of later school and professional adjustment. In the context of important investment made in the preschool curriculum to promote early academic achievement among children at risk of failure, the validity ...
Bigras, Marc, Capuano, France, Gosselin, Catherine, Normandeau, Sylvie, Parent, Sophie   +4 more
core  

The effectiveness of academic counseling based on a narrative approach on academic resilience and academic emotions of students with academic failure

Journal of Adolescent and Youth Psychological Studies, 2022
Background and Aim: Students experience different emotions in academic situations. Emotions are always present in educational and clinical environments. Academic resilience also refers to high levels of motivation for progress and performance, despite limited conditions.
Mohammad Amin Astereki, Mahshid Izadi, Mozhgan Mardani Rad, Mehdi Zare Bahramabadi   +3 more
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Educational potential, underachievement, and cultural pluralism [PDF]

, 2008
The term 'underachievement' is widespread in modern educational discourse, invoked most frequently in relation to a perceived failure to reach 'potential'.
Gillies, Donald
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Perspectivist Chicano Studies, 1970-1985 [PDF]

, 1996
This essay examine the development and failure of Perspectivist Chicano Studies. By the late 1960s Chicano(a) academics constructed several views of Chicano Studies.
Soldatenko, Michael
core   +1 more source