Results 51 to 60 of about 228,273 (260)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Association between family functioning and academic burnout among vocational college nursing students: mediating role of academic self-efficacy

Frontiers in Medicine
IntroductionAcademic burnout is not uncommon and interferes with the role shift from nursing students to qualified nurses, aggravating a shortage of workforce in global healthcare system.
Yanying Yang, Sujiao Liu, Min Zhou, Lihong Miao, Xuejuan Liu   +4 more
doaj   +1 more source

Modeling students\' academic self-regulation based on family functioning, school climate and psychological hardiness with the mediating role of academic self-efficacy

مجله علوم روانشناختی, 2022
Background: Much research has been done on the factors affecting students' academic self-regulation, but no study has been conducted that simultaneously examines the interactive effect of family functioning, school climate, psychological hardiness and ...
Ali Shahravi, Afsaneh Ghanbari panah, Mohammad Mahdi Shariat Bagheri, Shirin Koushki   +3 more
doaj  

Relationship among academic accomplishment, family functions, and academic perfectionism

Iranian Journal of Educational Research, 2023
This research delves into the intricate relationship among academic accomplishment, family functions, and academic perfectionism in a cohort of 154 university students enrolled at the University of Hormozgan in 2022. Employing regression analysis, the study seeks to elucidate the interconnections among these variables.
openaire   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Level and relationships of academic skills and family functions with academic performance during Covid 19 pandemic

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background The research indicates that academic skills and family function may influence academic achievement. The Covid 19 epidemic has impacted regular academic and family function.
Muath A. Alammar, Dushad Ram, Ibrahim Abdulrahman Almansour, Abdulrhman Saad Aljammaz   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Impact of family functioning and academic self-efficacy on maladaptive behaviors and depressive symptoms in rural adolescents

Acta Psychologica
This study examines bidirectional relationships between academic self-efficacy, family functioning, maladaptive behaviors and depressive symptoms among rural adolescents.
Jiaqi Zong, Ying Wang, Miaomiao Zhao, Qingyun Lu, Xiyue Wang, Jianlin Gao, Lingling Pan, Yuexia Gao   +7 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source