Results 51 to 60 of about 7,750,837 (306)

The Paradox of Active Procrastination: A Cross-Sectional Study of Perceived Task Control Among Psychology Students

Societies
Procrastination is commonly conceptualized as a maladaptive self-regulatory failure associated with impaired performance and reduced control over task execution.
Tomasz Jurys, Karolina Krupa-Kotara, Beata Nowak, Zofia Spandel, Joanna Szołtysek, Mateusz Grajek   +5 more
doaj   +1 more source

The functioning of academic employees in a dynamic South African higher education environment

Frontiers in Education, 2023
IntroductionThe higher education sector is experiencing changes in the profile of employees and stakeholders. Current employees are expected to function effectively and efficiently in institutions to achieve individual and organisational goals.
Thapelo D. ChaaCha, Thapelo D. ChaaCha, Elrie Oosthuysen, Elrie Oosthuysen   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Modeling students\' academic self-regulation based on family functioning, school climate and psychological hardiness with the mediating role of academic self-efficacy

مجله علوم روانشناختی, 2022
Background: Much research has been done on the factors affecting students' academic self-regulation, but no study has been conducted that simultaneously examines the interactive effect of family functioning, school climate, psychological hardiness and ...
Ali Shahravi, Afsaneh Ghanbari panah, Mohammad Mahdi Shariat Bagheri, Shirin Koushki   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Association between family functioning and academic burnout among vocational college nursing students: mediating role of academic self-efficacy

Frontiers in Medicine
IntroductionAcademic burnout is not uncommon and interferes with the role shift from nursing students to qualified nurses, aggravating a shortage of workforce in global healthcare system.
Yanying Yang, Sujiao Liu, Min Zhou, Lihong Miao, Xuejuan Liu   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

How does family functioning contribute to academic-related outcomes of Chinese adolescents: the mediating role of spirituality

Frontiers in Psychology
While family functioning is crucial to adolescent developmental outcomes, the mediating role of spirituality in the relationship between family functioning and academic-related outcomes of adolescents has been sparsely explored, particularly in non ...
Daniel T. L. Shek, Kim Hung Leung, Xiang Li, Diya Dou, Xiaoqin Zhu   +4 more
doaj   +1 more source

Relationship among academic accomplishment, family functions, and academic perfectionism

Iranian Journal of Educational Research, 2023
This research delves into the intricate relationship among academic accomplishment, family functions, and academic perfectionism in a cohort of 154 university students enrolled at the University of Hormozgan in 2022. Employing regression analysis, the study seeks to elucidate the interconnections among these variables.
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source