Results 71 to 80 of about 9,198,544 (347)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Despre „aventura italiană” in Moldova
Plural: History, Culture, Society, 2015 About "Italian Adventure" in ...
Ludmila Kojușko
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sovereign Court of Vasily III: Historical and Genealogical Research
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017 The research is focused on the issues concerning personal and genealogical composition of the Sovereign court during the great reign of Vasily the Third (1505–1533).
Aleksandr L. Korzinin, Nikita V. Bashnin
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
About Problems and Prospects of Humanities and Humanitarian Education in Russia
Высшее образование в России, 2019 The article presents reflections on the problems and prospects of humanities and humanitarian education in Russia, taking into account the basic program documents of the Russian state in the field of science and education.
O. V. Vorobieva
doaj +1 more source
Paradigms of History. Academic Antigypsyism, and Resistance [PDF]
KWI-BlogThis article outlines the international development, various eras, and positions of Romani people in social science, tracing the trajectory from the establishment of Gypsylorism totoday’s Critical Romani Studies and scholarship, all within the context of academic antigypsyism.
openaire +3 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Framing Collaboration: Archives, IRs, and General Collections [PDF]
, 2016 Collaborative collecting highlights the opportunity for liaison librarians and archivists in academic libraries to develop an integrated and holistic approach to the successful collection of library materials. Yet as academic libraries become the central
Baillargeon, Tara +3 more
core +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source