Results 41 to 50 of about 3,863,789 (356)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Exploring Academic Culture: Unpacking its Definition and Structure (A Systematic Scoping Review)

Journal of Language and Education, 2023
Background: The concept of academic culture lacks a standardised definition, and its structural components have not been clearly outlined or universally agreed upon.
Elena Tikhonova, Marina Kosycheva, Petr Kasatkin   +2 more
doaj   +1 more source

The Relationships between High School Subjects in terms of School Satisfaction and Academic Performance in Mexican Adolescents [PDF]

, 2019
Adolescents’ academic performance and the way it is related to their subjective wellbeing are issues of great interest across educational systems. The purpose of this study was to ascertain how satisfaction with high school subjects can predict school ...
Baena Extremera, Antonio, Baños, Raúl, Granero Gallegos, Antonio   +2 more
core   +1 more source

The Current State of Performance Appraisal Research and Practice: Concerns, Directions, and Implications [PDF]

, 1992
On the surface, it is not readily apparent how some performance appraisal research issues inform performance appraisal practice. Because performance appraisal is an applied topic, it is useful to periodically consider the current state of performance ...
Angel, N. E, Bedeian, A. G., Bemardin, H. J., Bemardin, H. J., Bernardin, H. J., Bernardin, H. J., Buford, J. A., Campbell, D. J., Cayer, M., Cocheu, T., Day, D., Dearden, J., Deets, N. R., Deming, E., DeNisi, A. S., Derven, M. G., Edwards, M. R., Edwards, M. R., Edwards, M. R., Eyres, P. S., Friedman, M. G., Galin, A., Gellerman, S. W., George T. Milkovich, Gibb, P., Girard, R., Goddard, R. W., Gomez-Mejia, L. R., Goodell, R., Greenberg, J., Greenberg, J., Hall, T. C., Harper, S. C., Howard, C. G., Kane, J. S., Kane, J. S., Kaufman, R., Kerr, J. L., Kirkpatrick, D. L., Krein, T. J., Kroll, M., Landy, E S., Lanza, P., Laumeyer, J., Lawrie, J., Lawrie, J. W., Lee, C., Lee, C., Levy, M., Locher, A. H., Locke, E. A., Longenecker, C. O., Lord, R. G., Lowe, T. R., McEvoy, G. M., Metz, E. J., Milkovich, G. T., Milkovich, G. T., Moen, R. D., Moss, S. M., Naffziger, D. W., Olian, J. D., Oliver, J. E., Reed, P. R., Regel, R. W., Reinhardt, C., Robert D. Bretz, Rodgers, T. J., Romanoff, K. E., Sahl, R. J., Sandler, L., Scherkenbach, W. W., Schneier, C. E., Schneier, C. E., Schneier, C. E., Scholtes, P. R., Schrader, A. W., Schweiger, D. M., Shapiro, G. L., Slattery, P. D., Tafti, P. M., Thorndike, R. L., Vines, L. S., Vinton, K. L., Vroom, V. H., Wagel, W. H., Waldman, D. A., Walter Read, Wehrenberg, S. B., Wexley, K. N., Wherry, R. J., Wight, D. T., Woods, J. G., Wyatt Company, The   +93 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The Effect of UNH Undergraduate Student Exercise on Academic Achievement [PDF]

, 2014
A number of existing studies focus on the effect exercise and dietary habits have on social relationships; however, few studies examine the relationship between exercise and academic performance on college students.
Pacheco, Nicolas
core   +2 more sources

When organisational effectiveness fails: business continuity management and the paradox of performance [PDF]

, 2017
Purpose: The aim of the paper is to consider the nature of the business continuity management (BCM) process and to frame it within wider literature on the performance of socio-technical systems.
Fischbacher-Smith, Denis
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The evaluation of lecturer’s improvement programs through academic culture and services

Jurnal Penelitian dan Evaluasi Pendidikan, 2022
This study evaluated the program to improve postgraduate lecturers’ performance at Muhammadiyah University Prof. Dr. Hamka (UHAMKA). This study used a mixed-method sequential explanatory design.
Connie Chairunnisa, Istaryatiningtias Istaryatiningtias   +1 more
doaj   +1 more source