Results 71 to 80 of about 13,766,670 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Relationship between Academic Self-efficacy and Motivation among Medical Science Students [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Academic motivation and its underlying factors have long been the major concern of educational institutions. Self-efficacy has been a key factor contributing to academic motivation, the students’ interest, and their academic performance ...
Zahra Taheri-Kharameh, Fatemeh Sharififard, Hamid Asayesh, Mohammadreza Sepahvandi, Mahsa Hajimohamad Hoseini   +4 more
doaj   +1 more source

Academic performance and behavioral patterns [PDF]

EPJ Data Science, 2018
Identifying the factors that influence academic performance is an essential part of educational research. Previous studies have documented the importance of personality traits, class attendance, and social network structure. Because most of these analyses were based on a single behavioral aspect and/or small sample sizes, there is currently no ...
Valentin Kassarnig, Enys Mones, Andreas Bjerre-Nielsen, Piotr Sapiezynski, David Dreyer Lassen, Sune Lehmann   +5 more
openaire   +6 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Competencies of Instructors: Its Correlation to the Factors Affecting the Academic Performance of Students

JPAIR, 2011
The study determined the competencies of instructors and its correlation to the factors affecting the academic performance of students in Western Mindanao State University- External Studies Units, Western Mindanao, Philippines.
Melrose A. Sali-Ot
doaj   +1 more source

Scholarly productivity of faculty in primary care roles related to tenure versus non-tenure tracks

BMC Medical Education, 2020
Background Increasing the number of primary care physicians is critical to overcoming the shortage of healthcare providers. Primary care physicians are increasingly called upon to address not only medical concerns but also behavioral health needs and ...
Michaela M. Braxton, Jhojana L. Infante Linares, Dmitry Tumin, Kendall M. Campbell   +3 more
doaj   +1 more source

Diet Quality and Academic Performance* [PDF]

Journal of School Health, 2008
ABSTRACTBackground:  Although the effects of nutrition on health and school performance are often cited, few research studies have examined the effect of diet quality on the academic performance of children. This study examines the association between overall diet quality and academic performance.Methods:  In 2003, 5200 grade 5 students in Nova Scotia,
Michelle D, Florence, Mark, Asbridge, Paul J, Veugelers   +2 more
openaire   +2 more sources

The Relationship Between Executive Functions and Academic Performance in Primary Education: Review and Meta-Analysis

Frontiers in Psychology, 2019
The purpose of this study was to research the relationship between executive functions and academic performance in primary education (6–12 years). Based on 21 samples (n = 7,947), a meta-analysis of random effects demonstrated a moderately significant ...
Alejandra Cortés Pascual, Nieves Moyano Muñoz, Alberto Quílez Robres   +2 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source