Results 41 to 50 of about 3,046,992 (302)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Promoting Personal Learning Environment for Emerging Academic Writing for Publication for Higher Education Students

open access: yesRegister Journal, 2020
Academic writing for publication in higher education is cognitively and linguistically complex. University students grapple with academic writing for publication because of academic genre/convention, linguistic competence, and academic literacy among ...
Nur Arifah Drajati   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Writing with Purpose(s): A Reflection on Different Conceptions of Academic Writing in Contemporary Higher Education

open access: yesIrish Journal of Academic Practice, 2017
Educational research literature presents three theoretical approaches for understanding academic writing. These are: writing as text, writing as process and writing as social practice.
Ita Kennelly
doaj   +1 more source

A Few Comments on Disciplinary Differences in Academic Publishing. Ken Hyland and Feng K. Jiang. Academic Discourse and Global Publishing. Disciplinary Persuasion in Changing Times. New York: Routledge, 2019, pp. 261.

open access: yesNew Horizons in English Studies, 2021
The review explores essential reading for students and teachers - Disciplinary persuasion in changing times by Ken Hyland and Feng Jiang. This book provides a comprehensive review of the main diciplinary practices in academic discourse and shows how ...
Zuzana Kozáčiková
doaj   +1 more source

Why do less creative student writers write longer texts? [PDF]

open access: yes, 2011
When teaching academic writing in English the issue of creativity understood as experimenting, exploring and transforming language and ideas within the required writing task while keeping the audience and purpose in mind is rarely, if ever, considered ...
Adams-Tukiendorf, Małgorzata
core  

Reflective writing: a management skill [PDF]

open access: yes, 2010
Purpose – The purpose of this paper is to analyze students' reflective writing in terms of identifiable outcomes and explore students' thoughts on reflection and reflective writing as a process.
Sen, B.A.
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Reaching In, Reaching Out: A Tale of Administrative Experimentation and the Process of Administrative Inclusion [PDF]

open access: yes, 2010
Universities often have a variety of academic programs and initiatives dedicated to the goal of helping students achieve effective communication skills, but these programs and initiatives can change quickly during different moments of institutional and ...
PreJean, Kelli
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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