Results 51 to 60 of about 1,008,210 (314)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Observed and perceived benefits of providing physical activity opportunities in elementary schools: a qualitative study

Frontiers in Sports and Active Living, 2023
IntroductionSchools play an important role in promoting physical activity for youth. However, school-based physical activity opportunities often compete with other academic priorities, limiting their implementation.
Timothy J. Walker, Derek W. Craig, Christopher D. Pfledderer, Michael C. Robertson, Paula Cuccaro, Keisey Fumero, John B. Bartholomew   +6 more
doaj   +1 more source

Debunking the Myth of the Efficacy of “Push-down Academics”: How Rigid, Teacher-Centered, Academic Early Learning Environments Dis-Empower Young Children [PDF]

, 2018
The increased emphasis on higher academic standards in Early Childhood Education has changed the instructional landscape and developed myths of quality learning.
Harmon, Flora, Viruru, Radhika
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Clinical Manifestations of Wegener Granulomatosis in Iranian Ethnicities Using the K-Means Algorithm: A Descriptive Study

International Archives of Otorhinolaryngology
Introduction Wegener granulomatosis (WG) appears with clinical symptoms, including recurrent respiratory infection, renal manifestations, and nonspecific systemic symptoms.
Fahimeh Khedmatkon, Samira Alesaeidi, Fatemeh Hajialiasgari, Jaleh Shoshtarian Malak   +3 more
doaj   +1 more source

Research into the diversification of university careers in learning and teaching and intentionally closing-the-loop on graduate employability

Journal of Teaching and Learning for Graduate Employability, 2019
Universities are both a source of employable graduates and careers. This paper examines universities as developers and employers of their own graduates from the perspective of employees and recruited positions.
James Arvanitakis, Madelaine-Marie Judd, Shelley Kinash, Trina Jorre de st Jorre, Trish McCluskey   +4 more
doaj   +1 more source

Exceeding Workplace-related Issues: Psychological Contract Breach and Its Effects as Experienced by Indonesian Academics

Revenue, 2023
The main objective of this research is to examine how Indonesian academics experienced breaches in their psychological contract, and how the breaches affected them.
Yayan Firmansah, Zabeda Abdul Hamid, Suhaimi Mhd Sarif   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Los académicos como agentes de cambio institucional: el caso del Instituto Tecnológico de Sonora, 2003-2018

Región y Sociedad, 2020
El objetivo de este artículo es analizar los cambios institucionales en el Instituto Tecnológico de Sonora entre 2003 y 2018. La metodología empleada es el estudio de caso, además de fuentes primarias y entrevistas semiestructuradas; este método limita ...
Gabriel Galindo Padilla, Juan Poom Medina   +1 more
doaj   +1 more source

Translational Research Communication: a new experience [PDF]

, 2014
Academics are like optical fibre. They generate communication about their research along exceptionally narrow channels. Their research communication is almost exclusively focused on their discipline – to their conferences and their journals.
Hofmeyr, Sally
core