Results 61 to 70 of about 3,619 (165)

Role of acamprosate in sensorineural tinnitus

open access: yesIndian Journal of Pharmacology, 2012
Acamprosate with dual mechanism of action as glutamate antagonist and GABA agonist can be a potential target to decrease the severity of sensorineural tinnitus.(1)To study the effectiveness of acamprosate in providing subjective relief and objective improvement in patients having tinnitus of sensorineural origin.
Sharma, Dinesh Kumar   +3 more
openaire   +3 more sources

The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats

open access: yesAddiction Biology, Volume 31, Issue 4, April 2026.
This study examined the effects of donepezil on mesolimbic dopamine signalling and alcohol‐related behaviours in male rats. Donepezil increases nucleus accumbens dopamine via muscarinic mechanisms and prevented further dopamine elevation after alcohol administration. Although it did not reduce regular alcohol intake, it abolished relapse‐like drinking.
Anna Loftén   +4 more
wiley   +1 more source

Correlates of baclofen effectiveness in alcohol dependence

open access: yesIndian Journal of Psychological Medicine, 2015
Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201) or Baclofen (348).
Lekhansh Shukla   +6 more
doaj   +1 more source

ACAMPROSATE AND BACLOFEN WERE NOT EFFECTIVE IN THE TREATMENT OF PATHOLOGICAL GAMBLING: PRELIMINARY BLIND RATER COMPARISON STUDY

open access: yesFrontiers in Psychiatry, 2011
Objectives: Pathological gambling (PG) is a highly prevalent and disabling impulse control disorder. A range of psychopharmacological options are available for the treatment of PG, including selective serotonin reuptake inhibitors (SSRI), opioid receptor
Pinhas N Dannon, Pinhas N Dannon
doaj   +1 more source

Acamprosate for the treatment of alcohol dependence

open access: yesClinical Therapeutics, 2005
Both inpatient and outpatient treatment centers that focus solely on psychosocial therapies for the treatment of alcohol dependence have high relapse rates. Thus, extensive research has focused on the development of pharmacologic moieties to attenuate the craving for alcohol after acute alcohol detoxification.
Harrison School of Pharmacy, Auburn University, Auburn, Alabama, and Columbus Regional Healthcare System, Columbus, Georgia, USA ( host institution )   +2 more
openaire   +3 more sources

Acamprosate in the treatment of alcoholism: a budget impact analysis for the National Health Service in Italy

open access: yesSubstance Abuse and Rehabilitation, 2012
Giorgio L Colombo,1,2 Sergio Di Matteo,2 Giacomo Bruno21Department of Drug Sciences, School of Pharmacy, University of Pavia, Pavia, Italy; 2S.A.V.E. – Studi Analisi Valutazioni Economiche, Milan, ItalyObjective: Alcohol dependence is a common ...
Colombo GL, Di Matteo S, Bruno G
doaj  

Tratamento farmacológico da dependência do álcool The pharmacologic treatment of the alcohol dependence

open access: yesBrazilian Journal of Psychiatry, 2004
As intervenções farmacológicas podem ter um papel crucial na redução do craving, consumo de álcool e manutenção da abstinência. Este artigo revisa a farmacoterapia para a dependência de álcool com ênfase na naltrexona, dissulfiram e acamprosato.
Luís André Castro   +1 more
doaj   +1 more source

Pharmacogenetics of alcohol addiction: current perspectives

open access: yesThe Application of Clinical Genetics, 2019
M S Zastrozhin,1,2 V Yu Skryabin,1 S S Miroshkin,1,2 E A Bryun,1,2 D A Sychev1,21Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow 109390, Russian Federation; 2Department of Addictology ...
Zastrozhin MS   +4 more
doaj  

Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

open access: yesCell Genomics
Summary: Repeat expansions in the C9orf72 gene are the most common genetic cause of (ALS) and frontotemporal dementia (FTD). Like other genetic forms of neurodegeneration, pinpointing the precise mechanism(s) by which this mutation leads to neuronal ...
Sara Saez-Atienzar   +325 more
doaj   +1 more source

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